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Aurora/JAK 抑制剂

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产品目录号: A10095


产品名 目录号 价格 数量
AT9283 5mg A10095-5
¥ 800.00
AT9283 10mg A10095-10
¥ 1,500.00
AT9283 25mg A10095-25
¥ 2,600.00
AT9283 100mg A10095-100
¥ 6,800.00
AT9283 10mM * 1mL in DMSO A10095-10mM-D
¥ 1,200.00



AT9283 inhibits aurora kinase A and B and targets other tyrosine and serine/threonine kinases associated with myeloid cell proliferation.





顾客使用 Adooq 产品发表的高质量科研文献

Chemical Information

目录号 A10095
Mechanism of action Inhibitor
分子量 381.4
化学分子式 C19H23N7O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 896466-04-9
Synonyms N/A
化学名称 1-cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea


AT9283 inhibits aurora kinase A and B and targets other tyrosine and serine/threonine kinases associated with myeloid cell proliferation.
Target Value
JAK3IC50: 1.1nM
JAK2IC50: 1.2nM
AuroraAIC50: ~3.0nM
AuroraBIC50: ~3.0nM
Abl1(T315I)IC50: 4nM
GSK-3βIC50: 1nM-10nM
FGFR2IC50: 1-10nM
VEGFR3/FLT4IC50: 1nM-10nM
MerIC50: 1nM-10nM
RETIC50: 1nM-10nM
RSK2IC50: 1nM-10nM
RSK3IC50: 1nM-10nM
TYK2IC50: 1nM-10nM
YESIC50: 1nM-10nM
Abl(Q252H)IC50: 10nM-30nM
DRAK1IC50: 10nM-30nM
FGFR1IC50: 10nM-30nM
FGFR1(V561M)IC50: 10nM-30nM
FGFR2(N549H)IC50: 10nM-30nM
FGFR3IC50: 10nM-30nM
VEGFR1/FLT1IC50: 10nM-30nM
FLT3IC50: 10nM-30nM
PDGFRα(D842V)IC50: 10nM-30nM
PDK-1IC50: 10nM-30nM
PKCμIC50: 10nM-30nM
RSK4IC50: 10nM-30nM
Src(T341M)IC50: 10nM-30nM
VEGFR2IC50: 10nM-30nM


Solubility (25°C) * In vitro DMSO 76 mg/mL (199.25 mM)
Water <1 mg/mL (<1 mM)
Ethanol 38 mg/mL (99.62 mM)
In vivo 15% Captisol 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.22 mL 131.1 mL 262.19mL
0.5 mM 5.24 mL 26.22 mL 52.44 mL
1 mM 2.62 mL 13.11 mL 26.22 mL
5 mM 0.52 mL 2.62 mL 5.24 mL

*The above data is based on the productmolecular weight 381.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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