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Auglurant (VU0424238) is a novel and selective mGlu5 antagonist with an IC50 value of 11 nM (rat) and an IC50 value of 14 nM (human). Auglurant (VU0424238) has an acceptable CNS penetration.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 30.74 mL | 153.7 mL | 307.41 mL |
| 0.5 mM | 6.15 mL | 30.74 mL | 61.48 mL |
| 1 mM | 3.07 mL | 15.37 mL | 30.74 mL |
| 5 mM | 0.61 mL | 3.07 mL | 6.15 mL |
*The above data is based on the productmolecular weight 325.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A20958 |
|---|---|
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 325.3 |
| Formula | C16H12FN5O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1396337-04-4 |
| Synonyms | VU0424238, VU 0424238, VU-0424238 |
| SMILES | CC1=NC(C(NC2=CC=C(F)C=N2)=O)=CC(OC3=CN=CN=C3)=C1 |
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