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AUY922 (Luminespib, NVP-AUY922)

AUY922 (Luminespib, NVP-AUY922)

Name: AUY922 (Luminespib, NVP-AUY922)
SKU: A10659

目录号: A10659

HSP90 抑制剂

Product Citations (2)

AUY922 (Luminespib, NVP-AUY922) Chemical Structure

CAS NO. 747412-49-3

AUY922 (Luminespib,NVP-AUY922)是一种高效的HSP90抑制剂，在Hsp90 FP结合测定中的IC50 = 21 nM，并在体外抑制多种人类癌细胞系的增殖，GI50平均为9 nM。Luminespib (AUY-922, NVP-AUY922)是一种高效的HSP90抑制剂，无细胞试验中作用于HSP90α/β的IC50为13 nM /21 nM，对HSP90家族成员GRP94和TRAP-1具有稍弱的作用，与任何小分子HSP90配体均可紧密结合。

库存：现货

规格	价格	数量
5 mg	￥ 400.00
10 mg	￥ 700.00
25 mg	￥ 1,400.00
100 mg	￥ 3,500.00
10mM * 1mL in DMSO	￥ 750.00

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产品详情

生物活性

靶点信息

HSP90α (Cell-free assay)	HSP90β (Cell-free assay)
13 nM	21 nM

溶解度 *

In vitro (25°C)	DMSO	Warmed: 86 mg/mL (184.72 mM)
	Water	Insoluble
	Ethanol	29 mg/mL (62.28 mM)
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.48 mL	107.41 mL	214.82 mL
0.5 mM	4.3 mL	21.48 mL	42.96 mL
1 mM	2.15 mL	10.74 mL	21.48 mL
5 mM	0.43 mL	2.15 mL	4.3 mL

*The above data is based on the productmolecular weight 465.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10659
作用机制	Inhibitor (抑制剂)
M. Wt	465.5
Formula	C26H31N3O5
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	747412-49-3
Synonyms	VER-52296, AUY-922
SMILES	CCNC(=O)C1=C(/C(=C/2\C=C(C(=CC2=O)O)C(C)C)/ON1)C3=CC=C(C=C3)CN4CCOCC4