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AUY922 (Luminespib, NVP-AUY922)


HSP90 抑制剂

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产品目录号: A10659


产品名 目录号 价格 数量
AUY922 5mg A10659-5
¥ 400.00
AUY922 10mg A10659-10
¥ 700.00
AUY922 25mg A10659-25
¥ 1,400.00
AUY922 100mg A10659-100
¥ 3,500.00
AUY922 (NVP-AUY922) 10mM * 1mL in DMSO A10659-10mM-D
¥ 750.00



AUY922 (NVP-AUY922) is highly potent and oral inhibitor of Hsp90 with IC50=21 nM in Hsp90 FP binding assay and inhibits proliferation of various human cancer cell lines in vitro, with GI50 average 9 nM.

AUY922 (Luminespib, NVP-AUY922)




顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 AUY922 (Luminespib, NVP-AUY922) 发表的文献 (1)
  • Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107每113

Chemical Information

目录号 A10659
Mechanism of action Inhibitor
分子量 465.5
化学分子式 C26H31N3O5
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 747412-49-3
Synonyms VER-52296, AUY-922
SMILES code CCNC(=O)C1=C(/C(=C/2\C=C(C(=CC2=O)O)C(C)C)/ON1)C3=CC=C(C=C3)CN4CCOCC4
化学名称 5-(2,4-Dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide


AUY922 (NVP-AUY922) is highly potent and oral inhibitor of Hsp90 with IC50=21 nM in Hsp90 FP binding assay and inhibits proliferation of various human cancer cell lines in vitro, with GI50 average 9 nM.
HSP90α (Cell-free assay) HSP90β (Cell-free assay)
13 nM21 nM


Solubility (25°C) * In vitro DMSO 93 mg/mL heating (199.76 mM)
Water <1 mg/mL (<1 mM)
Ethanol 31 mg/mL (66.58 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.48 mL 107.41 mL 214.82mL
0.5 mM 4.3 mL 21.48 mL 42.96 mL
1 mM 2.15 mL 10.74 mL 21.48 mL
5 mM 0.43 mL 2.15 mL 4.3 mL

*The above data is based on the productmolecular weight 465.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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