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Avadomide (CC-122)是一种新的化学实体，称为多效性途径修饰剂，是一种具有抗肿瘤和免疫调节活性的弥散性大B细胞淋巴瘤（DLBCL）的新型药物。它的分子靶标是脑蛋白(cereblon，CRBN)，是cullin环E3泛素连接酶复合物CRL4CRBN的底物受体。
| In vitro | DMSO | 50 mg/mL (174.64 mM) | |
| Water | Insoluble | ||
| Ethanol | <1 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 34.93 mL | 174.65 mL | 349.3 mL |
| 0.5 mM | 6.99 mL | 34.93 mL | 69.86 mL |
| 1 mM | 3.49 mL | 17.46 mL | 34.93 mL |
| 5 mM | 0.7 mL | 3.49 mL | 6.99 mL |
*The above data is based on the productmolecular weight 286.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16854 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 286.29 |
| Formula | C14H14N4O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1015474-32-4 |
| Synonyms | CC122, CC 122 |
| SMILES | O=C(C(N1C(C)=NC2=C(C(N)=CC=C2)C1=O)CC3)NC3=O |
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