Avapritinib

Name: Avapritinib
SKU: A19505
Price: 245 CNY
Rating: 5 (288 reviews)

目录号: A19505

KIT and PDGFRA 抑制剂

Avapritinib（BLU-285）是一种高效、选择性强且口服生物利用度高的KIT和PDGFRA激活环突变激酶抑制剂，其半抑制浓度（IC50）分别为0.27纳摩尔（nM）针对KIT D816V和0.24纳摩尔（nM）针对PDGFRA D842V。

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Grouped product items
规格	价格	库存
1mg	¥245.00	现货
5mg	¥525.00	现货
10mg	¥945.00	现货
25mg	¥2,170.00	现货
50mg	¥2,905.00	现货
100mg	¥5,460.00	现货
500mg	¥15,225.00	现货
*10mM 1mL in DMSO**	¥1,470.00	现货
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Data Sheet

SDS

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生物活性

Discription

Avapritinib (BLU-285) is a highly potent, selective, and orally bioavailable KIT and PDGFRA activation loop mutant kinases inhibitor with IC50s of 0.27 and 0.24 nM for KIT D816V and PDGFRA D842V, respectively.

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A19505
分子式	C26H27FN10
分子量	498.56
CAS号	1703793-34-3
SMILES	CN1N=CC(C2=CN3C(C(N4CCN(C5=NC=C([C@@](C)(N)C6=CC=C(F)C=C6)C=N5)CC4)=NC=N3)=C2)=C1
其他名称	BLU-285, BLU 285, BLU285
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	61 mg/mL (122.35 mM)
	Water	Insoluble
	Ethanol	3 mg/mL
In vivo	2% DMSO+40% PEG 300+2% Tween 80+ddH2O	3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.06 mL	100.29 mL	200.58 mL
0.5 mM	4.01 mL	20.06 mL	40.12 mL
1 mM	2.01 mL	10.03 mL	20.06 mL
5 mM	0.4 mL	2.01 mL	4.01 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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