Avitinib (AC0010)

Name: Avitinib (AC0010)
SKU: A16826
Price: 245 CNY
Rating: 5 (288 reviews)

目录号: A16826

irreversible EGFR 抑制剂

Avitinib（AC0010）是一种基于吡咯嘧啶的不可逆EGFR抑制剂，对EGFR L858R/T790M双突变具有选择性，IC50值为0.18 nM，对野生型EGFR的抑制效力几乎高出43倍（IC50值为7.68 nM）。它具有可比的抗肿瘤活性和可容忍的毒性。

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Grouped product items
规格	价格	库存
2mg	¥245.00	现货
5mg	¥420.00	现货
10mg	¥770.00	现货
25mg	¥1,540.00	现货
50mg	¥2,555.00	现货
100mg	¥3,780.00	现货
*10mM 1mL in DMSO**	¥490.00	现货
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Data Sheet

SDS

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生物活性

Discription

Avitinib (AC0010) is a pyrrolopyrimidine-based irreversible EGFR inhibitor that is mutation-selective with IC50 value of 0.18 nM against EGFR L858R/T790M double mutations, nearly 43-fold greater potency over wild-type EGFR (IC50 value, 7.68 nM). It has comparable anti-tumor activity and tolerated toxicity.

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A16826
分子式	C26H26FN7O2
分子量	487.53
CAS号	1557267-42-1
SMILES	C=CC(NC1=CC=CC(OC2=C3C(NC=C3)=NC(NC4=CC=C(N5CCN(C)CC5)C(F)=C4)=N2)=C1)=O
其他名称	AC-0010, AC 0010, Abivertinib
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	90 mg/mL (184.6 mM)
	Water	Insoluble
	Ethanol	90 mg/mL (184.6 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.51 mL	102.56 mL	205.12 mL
0.5 mM	4.1 mL	20.51 mL	41.02 mL
1 mM	2.05 mL	10.26 mL	20.51 mL
5 mM	0.41 mL	2.05 mL	4.1 mL

Useful Calculator

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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