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AVL-292 benzenesulfonate是一种共价，高选择性，口服活性的Btk小分子抑制剂，IC50值为0.5 nM，选择性是其他测定激酶的1400倍以上。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.19 mL | 85.97 mL | 171.93 mL |
| 0.5 mM | 3.44 mL | 17.19 mL | 34.39 mL |
| 1 mM | 1.72 mL | 8.6 mL | 17.19 mL |
| 5 mM | 0.34 mL | 1.72 mL | 3.44 mL |
*The above data is based on the productmolecular weight 581.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15008 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 581.62 |
| Formula | C28H28FN5O6S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1360053-81-1 |
| Synonyms | AVL292 benzenesulfonate, AVL 292 benzenesulfonate |
| SMILES | COCCOC1=CC=C(C=C1)NC2=NC=C(C(=N2)NC3=CC(=CC=C3)NC(=O)C=C)F.C1=CC=C(C=C1)S(=O)(=O)O |
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