AX-024 hydrochloride

Name: AX-024 hydrochloride
SKU: A18332
Price: 140 CNY
Rating: 5 (288 reviews)

目录号: A18332

TNF receptor 抑制剂

AX-024 是一种口服可用的 TCR-Nck 互作抑制剂，能够选择性地抑制 TCR 触发的 T 细胞激活（IC50 值为 1 nM）。抑制即刻的 TCR 信号对于治疗广泛的人类 T 细胞介导的自身免疫和炎症性疾病具有潜力。

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Grouped product items
规格	价格	库存
1mg	¥140.00	现货
2mg	¥210.00	现货
5mg	¥315.00	现货
10mg	¥595.00	现货
25mg	¥1,365.00	现货
50mg	¥2,240.00	现货
100mg	¥4,340.00	现货
*10mM 1mL in DMSO**	¥910.00	现货
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Data Sheet

SDS

Other Forms of AX-024 hydrochloride

AX-024

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生物活性

Discription

AX-024 is an orally available inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation (IC50 value 1 nM). Inhibiting an immediate TCR signal has promise for treating a broad spectrum of human T cell-mediated autoimmune and inflammatory diseases.

Targets

Target	Value

产品信息

目录号	A18332
分子式	C21H23ClFNO2
分子量	375.8684
CAS号	1704801-24-0
SMILES	COC1=CC(C(C2=CC=C(F)C=C2)=C(CN3CCCC3)CO4)=C4C=C1.[H]Cl
其他名称	AX-024; AX 024; AX024 HCl; AX-024 hydrochloride
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	64 mg/mL (170.27 mM)
	Water	3 mg/mL (7.98 mM)
	Ethanol	15 mg/mL (39.91 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.61 mL	133.03 mL	266.05 mL
0.5 mM	5.32 mL	26.61 mL	53.21 mL
1 mM	2.66 mL	13.3 mL	26.61 mL
5 mM	0.53 mL	2.66 mL	5.32 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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