Axitinib

目录号: A10103

VEGFR inhibitor

Axitinib Chemical Structure

CAS NO. 319460-85-0

Axitinib is a small molecule tyrosine kinase inhibitor,which inhibits multiple targets, including VEGFR-1, VEGFR-2, VEGFR-3, platelet derived growth factor receptor (PDGFR), and cKIT (CD117).

库存: 现货

规格 价格 数量
50 mg
¥ 400.00
100 mg
¥ 700.00
250 mg
¥ 1,200.00
10mM * 1mL in DMSO
¥ 620.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

Axitinib is a small molecule tyrosine kinase inhibitor,which inhibits multiple targets, including VEGFR-1, VEGFR-2, VEGFR-3, platelet derived growth factor receptor (PDGFR), and cKIT (CD117).
Targets
Target Value
VEGFR1/FLT1IC50: 0.1nM
VEGFR2/Flk1IC50: 0.18nM
VEGFR2/KDRIC50: 0.2nM
VEGFR3IC50: 0.1nM-0.3nM
PDGFRβIC50: 1.6nM
KitIC50: 1.7nM
PDGFRαIC50: 5.0nM
CSF-1RIC50: 73nM
FLT3IC50: >1μM
In vitro (25°C) DMSO 35 mg/mL heating (90.56 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% CMC 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.87 mL 129.37 mL 258.73 mL
0.5 mM 5.17 mL 25.87 mL 51.75 mL
1 mM 2.59 mL 12.94 mL 25.87 mL
5 mM 0.52 mL 2.59 mL 5.17 mL

*The above data is based on the productmolecular weight 386.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10103
MECHANISM OF ACTION Inhibitor
M. Wt 386.5
Formula C22H18N4OS
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 319460-85-0
Synonyms AG 013736
SMILES CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)/C=C/C4=CC=CC=N4

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