AZ 3146

目录号: A11170

Mps1 inhibitor

AZ 3146 Chemical Structure

CAS NO. 1124329-14-1

AZ 3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM). It interferes with chromosome alignment and overrides spindle assembly checkpoint and also Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores.

库存: 现货

规格 价格 数量
5 mg
¥ 500.00
10 mg
¥ 800.00
50 mg
¥ 2,400.00
100 mg
¥ 4,500.00
10mM * 1mL in DMSO
¥ 900.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

AZ 3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM). It interferes with chromosome alignment and overrides spindle assembly checkpoint and also Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores.

Targets
Mps1
~35 nM
In vitro DMSO 28 mg/mL (61.87 mM)
Water <1 mg/mL (<1 mM)
Ethanol 91 mg/mL (201.08 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.1 mL 110.49 mL 220.97 mL
0.5 mM 4.42 mL 22.1 mL 44.19 mL
1 mM 2.21 mL 11.05 mL 22.1 mL
5 mM 0.44 mL 2.21 mL 4.42 mL

*The above data is based on the productmolecular weight 452.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11170
MECHANISM OF ACTION Inhibitor
M. Wt 452.55
Formula C24H32N6O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1124329-14-1
Synonyms AZ-3146
SMILES CN1CCC(CC1)OC2=CC(=C(C=C2)NC3=NC=C4C(=N3)N(C(=O)N4C)C5CCCC5)OC

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