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AZ 3146

促销

Mps1 抑制剂

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产品目录号: A11170

库存状态:中国现货中国现货

产品名 目录号 价格 数量
AZ 3146 5mg A11170-5
¥ 500.00
AZ 3146 10mg A11170-10
¥ 800.00
AZ 3146 50mg A11170-50
¥ 2,400.00
AZ 3146 100mg A11170-100
¥ 4,500.00
AZ 3146 10mM * 1mL in DMSO A11170-10mM-D
¥ 900.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

AZ 3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM). It interferes with chromosome alignment and overrides spindle assembly checkpoint and also Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores.

AZ 3146

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 AZ 3146 发表的文献 (2)
  • Kakihana A, .et al. Heat shock-induced mitotic arrest requires heat shock protein 105 for the activation of spindle assembly checkpoint, FASEB J, 2018, Nov 29:fj201801369R PMID: 30496702
  • Suzuki M, .et al. Effect of MPS1 Inhibition on Genotoxic Stress Responses in Murine Tumour Cells, Anticancer Res, 2016, Jun;36(6):2783-92 PMID: 27272789

Chemical Information

目录号 A11170
Mechanism of action Inhibitor
分子量 452.55
化学分子式 C24H32N6O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1124329-14-1
Synonyms AZ-3146
SMILES code CN1CCC(CC1)OC2=CC(=C(C=C2)NC3=NC=C4C(=N3)N(C(=O)N4C)C5CCCC5)OC
化学名称 9-Cyclopentyl-2-[[2-methoxy-4-[(1-m ethylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7, 9-dihydro-8H-purin-8-one

生物活性

Description

AZ 3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM). It interferes with chromosome alignment and overrides spindle assembly checkpoint and also Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores.

Targets
Mps1
~35 nM

溶解性

Solubility (25°C)* In vitro DMSO 28 mg/mL (61.87 mM)
Water <1 mg/mL (<1 mM)
Ethanol 91 mg/mL (201.08 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.1 mL 110.49 mL 220.97mL
0.5 mM 4.42 mL 22.1 mL 44.19 mL
1 mM 2.21 mL 11.05 mL 22.1 mL
5 mM 0.44 mL 2.21 mL 4.42 mL

*The above data is based on the productmolecular weight 452.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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