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AZ304

AZ304

Name: AZ304
SKU: A17225

目录号: A17225

dual BRAF 抑制剂

AZ304 Chemical Structure

CAS NO. 942507-42-8

AZ304 is a potent dual BRAF inhibitor targeting the kinase domains of wild type BRAF, V600E mutant BRAF. AZ304 exerted potent inhibitory effects on both wild type and V600E mutant forms of the serine/threonine-protein kinase BRAF, with IC50 values of 79?nM and 38?nM, respectively.

库存：现货

规格	价格	数量
5 mg	￥ 1,100.00
10 mg	￥ 2,000.00
50 mg	￥ 7,500.00
100 mg	￥ 12,000.00

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生物活性

溶解度 *

In vitro	DMSO	81 mg/mL (179.39 mM)
	Water	Insoluble
	Ethanol	5 mg/mL (11.07 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.15 mL	110.73 mL	221.47 mL
0.5 mM	4.43 mL	22.15 mL	44.29 mL
1 mM	2.21 mL	11.07 mL	22.15 mL
5 mM	0.44 mL	2.21 mL	4.43 mL

*The above data is based on the productmolecular weight 451.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A17225
作用机制	Inhibitor (抑制剂)
M. Wt	451.53
Formula	C27H25N5O2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	942507-42-8
Synonyms	AZ-304; AZ 304;
SMILES	O=C(NC1=CC=C(C)C(NC2=C3C=CC(OC)=CC3=NC=N2)=C1)C4=CC=CC(C(C)(C#N)C)=C4