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AZ505

SMYD2 抑制剂

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产品目录号: A13061

库存状态:中国现货中国现货

产品名 目录号 价格 数量
AZ505 5mg A13061-5
¥ 1,800.00
AZ505 10mg A13061-10
¥ 3,200.00
AZ505 50mg A13061-50
¥ 9,600.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

AZ505 is a potent and highly selective inhibitor of the oncogenic protein SMYD2(IC50=0.12 μM) with potential anticancer activity, >600 fold than SMYD3(IC50>83.3 μM); DOT1L(IC50>83.3 μM);EZH2(IC50>83.3 μM).

AZ505

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Chemical Information

目录号 A13061
Mechanism of action Inhibitor
分子量 577.54
化学分子式 C29H38Cl2N4O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1035227-43-0
Synonyms AZ 505, AZ-505
SMILES code C1CCC(CC1)N(CCNCCC2=C3C(=C(C=C2)O)NC(=O)CO3)C(=O)CCNCCC4=CC(=C(C=C4)Cl)Cl
化学名称 N-cyclohexyl-3-[2-(3,4-dichlorophenyl)ethylamino]-N-[2-[2-(5-hydroxy-3-oxo-4H-1,4-benzoxazin-8-yl)ethylamino]ethyl]propanamide

生物活性

Description
AZ505 is a potent and highly selective inhibitor of the oncogenic protein SMYD2(IC50=0.12 μM) with potential anticancer activity, >600 fold than SMYD3(IC50>83.3 μM); DOT1L(IC50>83.3 μM);EZH2(IC50>83.3 μM).

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.31 mL 86.57 mL 173.15mL
0.5 mM 3.46 mL 17.31 mL 34.63 mL
1 mM 1.73 mL 8.66 mL 17.31 mL
5 mM 0.35 mL 1.73 mL 3.46 mL

*The above data is based on the productmolecular weight 577.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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