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EGFR 抑制剂

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产品目录号: A15516


产品名 目录号 价格 数量
AZ5104 10mg A15516-10
¥ 800.00
AZ5104 25mg A15516-25
¥ 1,600.00
AZ5104 50mg A15516-50
¥ 2,780.00



AZ5104, the demethylated metabolite of AZD-9291, is a potent EGFR inhibitor with IC50 of <1 nM, 6 nM, 1 nM, and 25 nM for EGFR (L858R/T790M), EGFR (L858R), EGFR (L861Q), and EGFR (wildtype), respectively. Phase 1.





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Chemical Information

目录号 A15516
Mechanism of action Inhibitor
分子量 485.58
化学分子式 C27H31N7O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1421373-98-9
Synonyms AZ-5104, AZ 5104
化学名称 (Z)-N-(5-((4-(1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylimidic acid


AZ5104, the demethylated metabolite of AZD-9291, is a potent EGFR inhibitor with IC50 of <1 nM, 6 nM, 1 nM, and 25 nM for EGFR (L858R/T790M), EGFR (L858R), EGFR (L861Q), and EGFR (wildtype), respectively. Phase 1.
Target Value
EGFR(L858R/T790M)IC50: <1nM
EGFR(L861Q)IC50: 1nM
EGFR(L858R)IC50: 6nM
ErbB4IC50: 7nM
EGFR(wildtype)IC50: 25nM
ACK1IC50: 27nM
BLKIC50: 27nM
BRKIC50: 45nM
MNK2IC50: 62nM
IGF1-RIC50: 78nM
ALKIC50: 97nM
TECIC50: 118nM
FESIC50: 127nM
InsRIC50: 127nM
FLT3IC50: 129nM
BTKIC50: 132nM
FAKIC50: 136nM
MLK1IC50: 141nM
FLT4IC50: 142nM
PYK2IC50: 284nM
IRRIC50: 423nM
TxkIC50: 426nM
BMXIC50: 505nM
ITKIC50: 925nM
JAK3IC50: 1358nM


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.59 mL 102.97 mL 205.94mL
0.5 mM 4.12 mL 20.59 mL 41.19 mL
1 mM 2.06 mL 10.3 mL 20.59 mL
5 mM 0.41 mL 2.06 mL 4.12 mL

*The above data is based on the productmolecular weight 485.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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