Trusted by 10,000+ Scientists since 2006
微信关注
申请试用装

AZ5104

EGFR 抑制剂

0 Customer Reviews
产品目录号: A15516

库存状态:中国现货中国现货

产品名 目录号 价格 数量
AZ5104 10mg A15516-10
¥ 800.00
AZ5104 25mg A15516-25
¥ 1,600.00
AZ5104 50mg A15516-50
¥ 2,780.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

AZ5104, the demethylated metabolite of AZD-9291, is a potent EGFR inhibitor with IC50 of <1 nM, 6 nM, 1 nM, and 25 nM for EGFR (L858R/T790M), EGFR (L858R), EGFR (L861Q), and EGFR (wildtype), respectively. Phase 1.

AZ5104

双击上述图片即可查看完整大小

缩小
放大

更多视图

顾客使用 Adooq 产品发表的高质量科研文献

Chemical Information

目录号 A15516
Mechanism of action Inhibitor
分子量 485.58
化学分子式 C27H31N7O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1421373-98-9
Synonyms AZ-5104, AZ 5104
SMILES code CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CNC4=CC=CC=C43)OC
化学名称 (Z)-N-(5-((4-(1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylimidic acid

生物活性

Description
AZ5104, the demethylated metabolite of AZD-9291, is a potent EGFR inhibitor with IC50 of <1 nM, 6 nM, 1 nM, and 25 nM for EGFR (L858R/T790M), EGFR (L858R), EGFR (L861Q), and EGFR (wildtype), respectively. Phase 1.
Targets
Target Value
EGFR(L858R/T790M)IC50: <1nM
EGFR(L861Q)IC50: 1nM
EGFR(L858R)IC50: 6nM
ErbB4IC50: 7nM
EGFR(wildtype)IC50: 25nM
ACK1IC50: 27nM
BLKIC50: 27nM
BRKIC50: 45nM
MNK2IC50: 62nM
IGF1-RIC50: 78nM
ALKIC50: 97nM
TECIC50: 118nM
FESIC50: 127nM
InsRIC50: 127nM
FLT3IC50: 129nM
BTKIC50: 132nM
FAKIC50: 136nM
MLK1IC50: 141nM
FLT4IC50: 142nM
PYK2IC50: 284nM
IRRIC50: 423nM
TxkIC50: 426nM
BMXIC50: 505nM
ITKIC50: 925nM
JAK3IC50: 1358nM

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.59 mL 102.97 mL 205.94mL
0.5 mM 4.12 mL 20.59 mL 41.19 mL
1 mM 2.06 mL 10.3 mL 20.59 mL
5 mM 0.41 mL 2.06 mL 4.12 mL

*The above data is based on the productmolecular weight 485.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Ordering online

To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.

To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.

When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards.  We will then liaise with you or your purchasing department to confirm the order.

Found your products but not ready to order?

Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.

Ordering offline

You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order.  Our contact details are:

We require the following information to process your order:
  • The catalog number for each product. 
  • Your email address or fax number. 
  • Your name and telephone number. 
  • Shipping address and billing address.
  • Purchase order numbers.

产品标签

使用空格分隔标签。使用单引号(')标注词组。

Similar product(s)


Keywords:购买 AZ5104 | AZ5104 供应商 | 订购 AZ5104 | AZ5104 价格 | AZ5104 生产商 | 订单 AZ5104 | AZ5104 代理商 | 购买 1421373-98-9| 1421373-98-9 供应商 | 订购 1421373-98-9 | 1421373-98-9 价格 | 1421373-98-9 生产商 | 订单 1421373-98-9 | 1421373-98-9 代理商|buy AZ5104 | AZ5104 Supplier | purchase AZ5104 | AZ5104 cost | AZ5104 manufacturer | order AZ5104 | AZ5104 distributor | buy 1421373-98-9| 1421373-98-9 Supplier | purchase 1421373-98-9 | 1421373-98-9 cost | 1421373-98-9 manufacturer | order 1421373-98-9 | 1421373-98-9 distributor