AZ5104

Name: AZ5104
SKU: A15516
Price: 280 CNY
Rating: 5 (288 reviews)

目录号: A15516

EGFR 抑制剂

AZ5104 是 AZD-9291 的去甲基化代谢物，是一种强效的 EGFR 抑制剂，其 IC50 分别为 EGFR (L858R/T790M) <1 nM、EGFR (L858R) 6 nM、EGFR (L861Q) 1 nM 和 EGFR (wildtype) 25 nM。目前处于第一阶段临床试验。

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Grouped product items
规格	价格	库存
5mg	¥280.00	现货
10mg	¥420.00	现货
25mg	¥840.00	现货
50mg	¥1,330.00	现货
100mg	¥1,820.00	现货
200mg	¥2,275.00	现货
*10mM 1mL in DMSO**	¥315.00	现货
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Data Sheet

SDS

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生物活性

Discription

AZ5104, the demethylated metabolite of AZD-9291, is a potent EGFR inhibitor with IC50 of <1 nM, 6 nM, 1 nM, and 25 nM for EGFR (L858R/T790M), EGFR (L858R), EGFR (L861Q), and EGFR (wildtype), respectively. Phase 1.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A15516
分子式	C27H31N7O2
分子量	485.58
CAS号	1421373-98-9
SMILES	CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CNC4=CC=CC=C43)OC
其他名称	AZ-5104, AZ 5104
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	90 mg/mL (185.34 mM)
	Water	Insoluble
	Ethanol	Warmed: 21 mg/mL (43.24 mM)
In vivo	1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.59 mL	102.97 mL	205.94 mL
0.5 mM	4.12 mL	20.59 mL	41.19 mL
1 mM	2.06 mL	10.3 mL	20.59 mL
5 mM	0.41 mL	2.06 mL	4.12 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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