AZ628

目录号: A11063

Raf inhibitor

AZ628

AZ628 Chemical Structure

CAS NO. 878739-06-1

AZ628 is a RAF inhibitor with IC50 values: ca 30 nM for BRAF V600E and wild-type CRAF and 100 nM for wild-type BRAF.

库存: 现货

规格 价格 数量
5 mg
¥ 700.00
10 mg
¥ 1,100.00
25 mg
¥ 2,200.00
50 mg
¥ 3,600.00
10mM * 1mL in DMSO
¥ 750.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

AZ628 is a RAF inhibitor with IC50 values: ca 30 nM for BRAF V600E and wild-type CRAF and 100 nM for wild-type BRAF.
Targets
C-Raf-1 (Cell-free assay) B-Raf (V600E) (Cell-free assay) B-Raf (Cell-free assay)
29 nM34 nM105 nM
In vitro (25°C) DMSO 90 mg/mL (199.32 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.15 mL 110.74 mL 221.48 mL
0.5 mM 4.43 mL 22.15 mL 44.3 mL
1 mM 2.21 mL 11.07 mL 22.15 mL
5 mM 0.44 mL 2.21 mL 4.43 mL

*The above data is based on the productmolecular weight 451.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11063
MECHANISM OF ACTION Inhibitor
M. Wt 451.5
Formula C27H25N5O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 878739-06-1
Synonyms AZ-628
SMILES CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(C)(C)C#N)NC3=CC4=C(C=C3)N=CN(C4=O)C

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