AZ628

目录号: A11063

Raf 抑制剂

AZ628

AZ628 Chemical Structure

CAS NO. 878739-06-1

AZ628是一种RAF抑制剂,IC50值:BRAF V600E和野生型CRAF约为30 nM,野生型BRAF约为100 nM。

库存: 现货

规格 价格 数量
5 mg
¥ 700.00
10 mg
¥ 1,100.00
25 mg
¥ 2,200.00
50 mg
¥ 3,600.00
10mM * 1mL in DMSO
¥ 750.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

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AZ628是一种RAF抑制剂,IC50值:BRAF V600E和野生型CRAF约为30 nM,野生型BRAF约为100 nM。
靶点信息
C-Raf-1 (Cell-free assay) B-Raf (V600E) (Cell-free assay) B-Raf (Cell-free assay)
29 nM34 nM105 nM
In vitro (25°C) DMSO 80 mg/mL (177.17 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+40% PEG 300+2% Tween 80+ddH2O 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.15 mL 110.74 mL 221.48 mL
0.5 mM 4.43 mL 22.15 mL 44.3 mL
1 mM 2.21 mL 11.07 mL 22.15 mL
5 mM 0.44 mL 2.21 mL 4.43 mL

*The above data is based on the productmolecular weight 451.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11063
作用机制 Inhibitor (抑制剂)
M. Wt 451.5
Formula C27H25N5O2
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 878739-06-1
Synonyms AZ-628
SMILES CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(C)(C)C#N)NC3=CC4=C(C=C3)N=CN(C4=O)C

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