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AZD 2932

mutil-targeted protein tyrosine kinase 抑制剂

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产品目录号: A14156

库存状态:中国现货中国现货

产品名 目录号 价格 数量
AZD 2932 5mg A14156-5
¥ 700.00
AZD 2932 10mg A14156-10
¥ 1,200.00
AZD 2932 25mg A14156-25
¥ 2,400.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

AZD2932 is a potent and mutil-targeted protein tyrosine kinase inhibitor with IC50 of 8 nM, 4 nM, 7 nM, and 9 nM for VEGFR-2, PDGFRβ, Flt-3, and c-Kit, respectively.

AZD 2932

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Chemical Information

目录号 A14156
Mechanism of action Inhibitor
分子量 447.49
化学分子式 C24H25N5O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 883986-34-3
Synonyms AZD-2932,AZD2932
SMILES code CC(C)N1C=C(C=N1)NC(=O)CC2=CC=C(C=C2)OC3=NC=NC4=CC(=C(C=C43)OC)OC
化学名称 2-(4-((6,7-dimethoxyquinazolin-4-yl)oxy)phenyl)-N-(1-isopropyl-1H-pyrazol-4-yl)acetamide

生物活性

Description
AZD2932 is a potent and mutil-targeted protein tyrosine kinase inhibitor with IC50 of 8 nM, 4 nM, 7 nM, and 9 nM for VEGFR-2, PDGFRβ, Flt-3, and c-Kit, respectively.
Targets
PDGFRβ Flt3 VEGFR-2 c-Kit
4 nM7 nM8 nM9 nM

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.35 mL 111.73 mL 223.47mL
0.5 mM 4.47 mL 22.35 mL 44.69 mL
1 mM 2.23 mL 11.17 mL 22.35 mL
5 mM 0.45 mL 2.23 mL 4.47 mL

*The above data is based on the productmolecular weight 447.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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