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AZD-5904是一种有效的生物利用MPO抑制剂。在临床前研究中，AZD-5904以140 nM的IC50抑制了分离出的MPO酶，在大鼠和小鼠MPO酶活性的测定中具有大约等价性。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 39.64 mL | 198.18 mL | 396.37 mL |
| 0.5 mM | 7.93 mL | 39.64 mL | 79.27 mL |
| 1 mM | 3.96 mL | 19.82 mL | 39.64 mL |
| 5 mM | 0.79 mL | 3.96 mL | 7.93 mL |
*The above data is based on the productmolecular weight 252.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A17062 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 252.29 |
| Formula | C10H12N4O2S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 618913-30-7 |
| Synonyms | AZ1, AZ 1 AZ-1, TX4, TX-4, TX 4, AZD 5904, AZD5904 |
| SMILES | O=C1NC(N(C[C@H]2OCCC2)C3=C1NC=N3)=S |
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