AZD 7545
目录号: A14157
PDHK 抑制剂
AZD7545 是一种新型、选择性的小分子抑制剂，针对 PDHK2 (PDH激酶2)，其 IC50 分别为 PDHK1 的 36.8 nM 和 PDHK2 的 6.4 nM。
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生物活性
| Discription | AZD7545 is a novel, selective small-molecule inhibitor of PDHK2 (PDH kinase2) with an IC50 of 36.8 nM and 6.4 nM for PDHK1 and PDHK2 respectively. | ||
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产品信息
| 目录号 | A14157 |
|---|---|
| 分子式 | C19H18ClF3N2O5S |
| 分子量 | 478.87 |
| CAS号 | 252017-04-2 |
| SMILES | C[C@@](C(=O)NC1=C(C=C(C=C1)S(=O)(=O)C2=CC=C(C=C2)C(=O)N(C)C)Cl)(C(F)(F)F)O |
| 其他名称 | AZD-7545,AZD7545 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 92 mg/mL (192.12 mM) | |
| Water | Insoluble | ||
| Ethanol | 92 mg/mL (192.12 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.88 mL | 104.41 mL | 208.82 mL |
| 0.5 mM | 4.18 mL | 20.88 mL | 41.76 mL |
| 1 mM | 2.09 mL | 10.44 mL | 20.88 mL |
| 5 mM | 0.42 mL | 2.09 mL | 4.18 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 252017-04-2 | 252017-04-2 供应商 | 252017-04-2 花费 | 252017-04-2 生产商 | 订购 252017-04-2 | 252017-04-2 代理商