AZD-9291 (Osimertinib)

目录号: A13681

EGFR 抑制剂

AZD-9291 (Osimertinib)

AZD-9291 (Osimertinib) Chemical Structure

CAS NO. 1421373-65-0

AZD-9291 (Osimertinib)是第三代EGFR抑制剂,在临床前研究中显示出希望,并为已对现有EGFR抑制剂产生耐药性的晚期肺癌患者提供了希望。

库存: 现货

规格 价格 数量
5 mg
¥ 500.00
10 mg
¥ 700.00
50 mg
¥ 950.00
10mM * 1mL in DMSO
¥ 550.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

AZD-9291 (Osimertinib)是第三代EGFR抑制剂,在临床前研究中显示出希望,并为已对现有EGFR抑制剂产生耐药性的晚期肺癌患者提供了希望。
靶点信息
L858R/T790M EGFR (LoVo cells) Exon 19 deletion EGFR (LoVo cells) WT EGFR (LoVo cells)
11.44 nM12.92 nM493.8 nM
In vitro DMSO 99 mg/mL heating (198.15 mM)
Water <1 mg/mL (<1 mM)
Ethanol 43 mg/mL heating (86.06 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.02 mL 100.08 mL 200.16 mL
0.5 mM 4 mL 20.02 mL 40.03 mL
1 mM 2 mL 10.01 mL 20.02 mL
5 mM 0.4 mL 2 mL 4 mL

*The above data is based on the productmolecular weight 499.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A13681
作用机制 Inhibitor (抑制剂)
M. Wt 499.61
Formula C28H33N7O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1421373-65-0
Synonyms AZD 9291, AZD9291
SMILES CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC

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