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AZD-9291 (Osimertinib)

促销

EGFR 抑制剂

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产品目录号: A13681

库存状态:中国现货中国现货

产品名 目录号 价格 数量
AZD-9291 5mg A13681-5
¥ 500.00
AZD-9291 10mg A13681-10
¥ 700.00
AZD-9291 25mg A13681-25
¥ 1,000.00
AZD-9291 50mg A13681-50
¥ 1,200.00
AZD-9291 10mM * 1mL in DMSO A13681-10mM-D
¥ 550.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors.

AZD-9291 (Osimertinib)

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Chemical Information

目录号 A13681
Mechanism of action Inhibitor
分子量 499.61
化学分子式 C28H33N7O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1421373-65-0
Synonyms AZD 9291, AZD9291
SMILES code CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC
化学名称 N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide

生物活性

Description
AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors.
Targets
L858R/T790M EGFR (LoVo cells) Exon 19 deletion EGFR (LoVo cells) WT EGFR (LoVo cells)
11.44 nM12.92 nM493.8 nM

溶解性

Solubility (25°C)* In vitro DMSO 99 mg/mL heating (198.15 mM)
Water <1 mg/mL (<1 mM)
Ethanol 43 mg/mL heating (86.06 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.02 mL 100.08 mL 200.16mL
0.5 mM 4 mL 20.02 mL 40.03 mL
1 mM 2 mL 10.01 mL 20.02 mL
5 mM 0.4 mL 2 mL 4 mL

*The above data is based on the productmolecular weight 499.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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