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pan-Pim kinase 抑制剂

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产品目录号: A13203


产品名 目录号 价格 数量
AZD1208 5mg A13203-5
¥ 700.00
AZD1208 10mg A13203-10
¥ 1,000.00
AZD1208 25mg A13203-25
¥ 2,000.00
AZD1208 50mg A13203-50
¥ 3,500.00
AZD1208 10mM * 1mL in DMSO A13203-10mM-D
¥ 750.00



AZD1208 is orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity.





顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 AZD1208 发表的文献 (5)
  • Remy J, .et al. Inhibition of PIM1 blocks the autophagic flux to sensitize glioblastoma cells to ABT-737-induced apoptosis, Biochim Biophys Acta Mol Cell Res, 2019, Feb;1866(2):175-189 PMID: 30389373
  • Andrea L. Casillas, .et al. Hypoxia-inducible PIM kinase expression promotes resistance to anti-angiogenic agents, Clin Cancer Res, 2018, Jan 1; 24(1): 169每180 PMID: 29084916
  • Jin H. Song, .et al. Mechanisms Behind Resistance to PI3K Inhibitor Treatment Induced by the PIM Kinase, Mol Cancer Ther, 2018, Dec;17(12):2710-2721 PMID: 30190422
  • Sathish K.R. Padi, .et al. Targeting the PIM protein kinases for the treatment of a T-cell acute lymphoblastic leukemia subset, Oncotarget, 2017, May 2; 8(18): 30199每30216 PMID: 28415816
  • Lim R, .et al. Inhibition of PIM1 kinase attenuates inflammation-induced pro-labour mediators in human foetal membranes in vitro, Mol Hum Reprod, 2017, Jun 1;23(6):428-440 PMID: 28333279

Chemical Information

目录号 A13203
Mechanism of action Inhibitor
分子量 379.48
化学分子式 C21H21N3O2S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1204144-28-4
Synonyms AZD 1208, AZD-1208
SMILES code C1C[C@H](CN(C1)C2=C(C=CC=C2/C=C\3/C(=O)NC(=O)S3)C4=CC=CC=C4)N
化学名称 5-[[2-[(3R)-3-Aminopiperidin-1-yl]biphenyl-3-yl]methylidene]-1,3-thiazolidine-2,4-dione


AZD1208 is orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity.
Pim1 (Cell-free assay) Pim3 (Cell-free assay) Pim2 (Cell-free assay)
0.4 nM1.9 nM5 nM


Solubility (25°C)* In vitro DMSO 75 mg/mL heating (197.63 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.35 mL 131.76 mL 263.52mL
0.5 mM 5.27 mL 26.35 mL 52.7 mL
1 mM 2.64 mL 13.18 mL 26.35 mL
5 mM 0.53 mL 2.64 mL 5.27 mL

*The above data is based on the productmolecular weight 379.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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