AZD1390

Name: AZD1390
SKU: A16798
Price: 525 CNY
Rating: 5 (288 reviews)

目录号: A16798

ATM 抑制剂

AZD1390 是一种首创的口服可用且能穿透中枢神经系统（CNS）的 ATM 抑制剂，在细胞中的 IC50 为 0.78 nM，对于 PIKK 酶家族中的其他密切相关成员具有超过 10,000 倍的选择性，并且在广泛的激酶组中表现出极佳的选择性。

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Grouped product items
规格	价格	库存
1mg	¥525.00	现货
2mg	¥665.00	现货
5mg	¥1,085.00	现货
10mg	¥1,610.00	现货
25mg	¥3,360.00	现货
50mg	¥4,305.00	现货
100mg	¥5,530.00	现货
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Data Sheet

SDS

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生物活性

Discription

AZD1390 is a first-in-class orally available and CNS penetrant ATM inhibitor with an IC50 of 0.78 nM in cells and >10,000-fold selectivity over closely related members of the PIKK family of enzymes and excellent selectivity across a broad panel of kinases.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A16798
分子式	C27H32FN5O2
分子量	477.57
CAS号	2089288-03-7
SMILES	O=C(N1C(C)C)N(C)C2=C1C3=CC(C4=CC=C(OCCCN5CCCCC5)N=C4)=C(F)C=C3N=C2
其他名称	AZD-1390, AZD 1390
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	14 mg/mL (29.31 mM)
	Water	Insoluble
	Ethanol	93 mg/mL (194.73 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.94 mL	104.7 mL	209.39 mL
0.5 mM	4.19 mL	20.94 mL	41.88 mL
1 mM	2.09 mL	10.47 mL	20.94 mL
5 mM	0.42 mL	2.09 mL	4.19 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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