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JAK 抑制剂

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产品目录号: A10110


产品名 目录号 价格 数量
AZD1480 5mg A10110-5
¥ 500.00
AZD1480 10mg A10110-10
¥ 800.00
AZD1480 50mg A10110-50
¥ 2,000.00
AZD1480 200mg A10110-200
¥ 6,500.00
AZD1480 10mM * 1mL in DMSO A10110-10mM-D
¥ 940.00



AZD1480 is a novel potent small JAK2 inhibitor with an IC50 of 0.26 nM.





顾客使用 Adooq 产品发表的高质量科研文献

Chemical Information

目录号 A10110
Mechanism of action Inhibitor
分子量 348.8
化学分子式 C14H14ClFN8
Solubility DMSO>70mg/mL Water<1mg/mL Ethanol>5mg/mL
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 935666-88-9
Synonyms N/A
SMILES code CC1=CC(=NN1)NC2=NC(=NC=C2Cl)N[C@@H](C)C3=NC=C(C=N3)F
化学名称 5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine


AZD1480 is a novel potent small JAK2 inhibitor with an IC50 of 0.26 nM.
JAK2 (Cell-free assay)
0.26 nM


Solubility (25°C) * In vitro DMSO 69 mg/mL heating (197.83 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.67 mL 143.35 mL 286.7mL
0.5 mM 5.73 mL 28.67 mL 57.34 mL
1 mM 2.87 mL 14.33 mL 28.67 mL
5 mM 0.57 mL 2.87 mL 5.73 mL

*The above data is based on the productmolecular weight 348.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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