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AZD2014 (Vistusertib)

促销

mTORC1/2 抑制剂

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产品目录号: A11303

库存状态:中国现货中国现货

产品名 目录号 价格 数量
AZD2014 5mg A11303-5
¥ 700.00
AZD2014 10mg A11303-10
¥ 1,200.00
AZD2014 25mg A11303-25
¥ 2,500.00
AZD2014 50mg A11303-50
¥ 4,500.00
AZD2014 10mM * 1mL in DMSO A11303-10mM-D
¥ 700.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

AZD2014 is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. mTOR kinase inhibitor.

AZD2014 (Vistusertib)

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Chemical Information

目录号 A11303
Mechanism of action Inhibitor
分子量 462.5
化学分子式 C25H30N6O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1009298-59-2
Synonyms AZD-2014
SMILES code C[C@H]1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=CC=C4)C(=O)NC)N5CCOC[C@@H]5C
化学名称 3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide

生物活性

Description
AZD2014 is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. mTOR kinase inhibitor.
Targets
mTOR (Cell-free assay) P-Akt (S473) (Cell-free assay) pS6 (S235/236) (Cell-free assay)
2.8 nM80 nM200 nM

溶解性

Solubility (25°C) * In vitro DMSO 38 mg/mL (82.15 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.62 mL 108.11 mL 216.22mL
0.5 mM 4.32 mL 21.62 mL 43.24 mL
1 mM 2.16 mL 10.81 mL 21.62 mL
5 mM 0.43 mL 2.16 mL 4.32 mL

*The above data is based on the productmolecular weight 462.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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