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AZD3759

EGFR 抑制剂

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产品目录号: A15551

库存状态:中国现货中国现货

产品名 目录号 价格 数量
AZD3759 10mg A15551-10
¥ 800.00
AZD3759 25mg A15551-25
¥ 1,200.00
AZD3759 50mg A15551-50
¥ 1,500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

AZD3759 is an orally available inhibitor of the epidermal growth factor receptor (EGFR). It binds to and inhibits the activity of EGFR as well as certain mutant forms of EGFR.

AZD3759

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Chemical Information

目录号 A15551
Mechanism of action Inhibitor
分子量 459.9
化学分子式 C22H23ClFN5O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1626387-80-1
Synonyms AZD 3759
SMILES code CC1CN(CCN1C(=O)OC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C(=CC=C4)Cl)F)OC)C
化学名称 [4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl] (2R)-2,4-dimethylpiperazine-1-carboxylate

生物活性

Description
AZD3759 is an orally available inhibitor of the epidermal growth factor receptor (EGFR). It binds to and inhibits the activity of EGFR as well as certain mutant forms of EGFR.
Targets
EGFR (L858R) EGFR (exon 19Del) EGFR (WT)
0.2 nM0.2 nM0.3 nM

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.74 mL 108.72 mL 217.44mL
0.5 mM 4.35 mL 21.74 mL 43.49 mL
1 mM 2.17 mL 10.87 mL 21.74 mL
5 mM 0.43 mL 2.17 mL 4.35 mL

*The above data is based on the productmolecular weight 459.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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