AZD3839 free base

Name: AZD3839 free base
SKU: A21606

目录号: A21606

BACE1 inhibitor

AZD3839 free base Chemical Structure

CAS NO. 1227163-84-9

AZD3839 (free base) is a potent and selective BACE1 inhibitor with IC50 of 23.6 uM, about 14-fold selectivity over BACE2, also a β-secretase enzyme inhibitor.

库存：现货

规格	价格	数量
5 mg	￥ 1,400.00
10 mg	￥ 2,420.00
50 mg	￥ 7,180.00
100 mg	￥ 14,350.00

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产品仅用于科学研究，不针对患者销售，望谅解.

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生物活性

AZD3839 (free base) is a potent and selective BACE1 inhibitor with IC50 of 23.6 uM, about 14-fold selectivity over BACE2, also a β-secretase enzyme inhibitor.

溶解度 *

In vitro (25°C)	DMSO	79 mg/mL (183.11 mM)
	Water	Insoluble
	Ethanol	Warmed: 79 mg/mL (183.11 mM)
In vivo	5% dimethylacetamide and 20% hydroxypropyl-??-cyclodextrin in 0.3 M gluconic acid, pH 3, or 0.3 M gluconic acid, pH 3.	1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.18 mL	115.9 mL	231.8 mL
0.5 mM	4.64 mL	23.18 mL	46.36 mL
1 mM	2.32 mL	11.59 mL	23.18 mL
5 mM	0.46 mL	2.32 mL	4.64 mL

*The above data is based on the productmolecular weight 431.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A21606
作用机制	Inhibitor (抑制剂)
M. Wt	431.41
Formula	C24H16F3N5
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1227163-84-9
Synonyms	AZD 3839, AZD-3839
SMILES	FC1=C2C([C@](C3=CC=CC(C4=CN=CN=C4)=C3)(C5=CC(C(F)F)=NC=C5)N=C2N)=CC=C1