AZD4547

目录号: A11075

FGFR inhibitor

AZD4547

AZD4547 Chemical Structure

CAS NO. 1035270-39-3

AZD4547 is a potent, selective and orally active pan-FGFR inhibitor, with IC50s of 0.2, 2.5, 1.8 and 165 nM for FGFR1, 2, 3 and 4, respectively.

库存: 现货

规格 价格 数量
5 mg
¥ 500.00
10 mg
¥ 700.00
50 mg
¥ 1,400.00
100 mg
¥ 1,900.00
10mM * 1mL in DMSO
¥ 550.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

AZD4547 is a potent, selective and orally active pan-FGFR inhibitor, with IC50s of 0.2, 2.5, 1.8 and 165 nM for FGFR1, 2, 3 and 4, respectively.
Targets
Target Value
FGFR1IC50: 0.2nM
FGFR3IC50: 1.8nM
FGFR2IC50: 2.5nM
KDRIC50: 24nM
FGFR4IC50: 165nM
IGFRIC50: 581nM
AxlIC50: >2μM
CDK2IC50: >10μM
FAKIC50: >10μM
ROCK2IC50: >50μM
Akt1IC50: >100μM
ALK1IC50: >100μM
p38IC50: >100μM
PI3KαIC50: >100μM
In vitro (25°C) DMSO 92 mg/mL (198.45 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.57 mL 107.85 mL 215.7 mL
0.5 mM 4.31 mL 21.57 mL 43.14 mL
1 mM 2.16 mL 10.79 mL 21.57 mL
5 mM 0.43 mL 2.16 mL 4.31 mL

*The above data is based on the productmolecular weight 463.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

目录号 A11075
MECHANISM OF ACTION Inhibitor
M. Wt 463.6
Formula C26H33N5O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1035270-39-3
Synonyms AZD-4547
SMILES C[C@@H]1CN(C[C@@H](N1)C)C2=CC=C(C=C2)C(=O)NC3=NNC(=C3)CCC4=CC(=CC(=C4)OC)OC

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