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AZD4547

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FGFR 抑制剂

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产品目录号: A11075

库存状态:中国现货中国现货

产品名 目录号 价格 数量
AZD4547 5mg A11075-5
¥ 500.00
AZD4547 10mg A11075-10
¥ 700.00
AZD4547 50mg A11075-50
¥ 1,400.00
AZD4547 100mg A11075-100
¥ 1,900.00
AZD4547 10mM * 1mL in DMSO A11075-10mM-D
¥ 550.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

AZD4547 is a potent, selective and orally active pan-FGFR inhibitor, with IC50s of 0.2, 2.5, 1.8 and 165 nM for FGFR1, 2, 3 and 4, respectively.

AZD4547

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 AZD4547 发表的文献 (2)
  • Ryuma Tokunaga, .et al. Fibroblast growth factor receptor 2 expression, but not its genetic amplification, is associated with tumor growth and worse survival in esophagogastric junction adenocarcinoma, Oncotarget, 2016, Apr 12; 7(15): 19748每19761 PMID: 26933914
  • Mitsuko Kawano, .et al. FGF18 signaling in the hair cycle resting phase determines radioresistance of hair follicles by arresting hair cycling, Adv Radiat Oncol, 2016, Jul-Sep; 1(3): 170每181 PMID: 28740887

Chemical Information

目录号 A11075
Mechanism of action Inhibitor
分子量 463.6
化学分子式 C26H33N5O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1035270-39-3
Synonyms AZD-4547
SMILES code C[C@@H]1CN(C[C@@H](N1)C)C2=CC=C(C=C2)C(=O)NC3=NNC(=C3)CCC4=CC(=CC(=C4)OC)OC
化学名称 N-(5-(3,5-dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3S,5R)-3,5-dimethylpiperazin-1-yl)benzamide

生物活性

Description
AZD4547 is a potent, selective and orally active pan-FGFR inhibitor, with IC50s of 0.2, 2.5, 1.8 and 165 nM for FGFR1, 2, 3 and 4, respectively.
Targets
Target Value
FGFR1IC50: 0.2nM
FGFR3IC50: 1.8nM
FGFR2IC50: 2.5nM
KDRIC50: 24nM
FGFR4IC50: 165nM
IGFRIC50: 581nM
AxlIC50: >2μM
CDK2IC50: >10μM
FAKIC50: >10μM
ROCK2IC50: >50μM
Akt1IC50: >100μM
ALK1IC50: >100μM
p38IC50: >100μM
PI3KαIC50: >100μM

溶解性

Solubility (25°C) * In vitro DMSO 92 mg/mL (198.45 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.57 mL 107.85 mL 215.7mL
0.5 mM 4.31 mL 21.57 mL 43.14 mL
1 mM 2.16 mL 10.79 mL 21.57 mL
5 mM 0.43 mL 2.16 mL 4.31 mL

*The above data is based on the productmolecular weight 463.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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