Capivasertib (AZD5363)

Name: Capivasertib (AZD5363)
SKU: A11759
Price: 175 CNY
Rating: 5 (6 reviews)

目录号: A11759

AKT抑制剂

6 篇发表文献

Capivasertib (AZD5363) 是一种强效的 AKT 抑制剂，在体内具有药效活性，有潜力作为单药治疗或联合治疗药物，用于治疗多种实体瘤和血液肿瘤。

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Grouped product items
规格	价格	库存
1mg	¥175.00	现货
5mg	¥385.00	现货
10mg	¥665.00	现货
25mg	¥1,155.00	现货
50mg	¥1,750.00	现货
100mg	¥2,730.00	现货
500mg	¥7,805.00	现货
1g	¥14,700.00	现货
*10mM 1mL in DMSO**	¥525.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用Capivasertib (AZD5363)发表的6篇文献

Léa-Isabelle Renaud, .et al. , PLoS One, 2024, Jun 21;19(6):e0302042 PMID: 38905217

Majid Momeny, .et al. , EMBO Mol Med, 2024, Jun 17 PMID: 38886591

Hiroyuki Tsuchiya, .et al. , Curr Issues Mol Biol, 2023, Jan 29;45(2):1073-1085 PMID: 36826016

Giri R. Gnawali, .et al. , Medicinal Chemistry Research, 2022, 31: 1154-1175

Jeremiah J Bearss, .et al. , EMBO Rep, 2021, Apr 7;22(4):e50835 PMID: 33586867

Jin H. Song, .et al. , Mol Cancer Ther, 2018, Dec;17(12):2710-2721 PMID: 30190422

生物活性

Discription

Capivasertib (AZD5363) is a potent inhibitor of AKT with pharmacodynamic activity in vivo, has potential to treat a range of solid and hematologic tumors as monotherapy or a combinatorial agent.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A11759
分子式	C21H25ClN6O2
分子量	428.9
CAS号	1143532-39-1
SMILES	C1CN(CCC1(C(=O)N[C@@H](CCO)C2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4
其他名称	AZD 5363, AZD-5363
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	79 mg/mL (184.18 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.32 mL	116.58 mL	233.15 mL
0.5 mM	4.66 mL	23.32 mL	46.63 mL
1 mM	2.33 mL	11.66 mL	23.32 mL
5 mM	0.47 mL	2.33 mL	4.66 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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