AZD6244 (Selumetinib)

Name: AZD6244 (Selumetinib)
SKU: A10257
Price: 280 CNY
Rating: 5 (1 reviews)

目录号: A10257

MEK 抑制剂

1 篇发表文献

AZD6244（Selumetinib），也被称为Selumetinib、ARRY142886、AZD-6244和ARRY-142886，是一种MEK 1/2 抑制剂，其GI50值在14到50纳摩尔之间。

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Grouped product items
规格	价格	库存
25mg	¥280.00	现货
50mg	¥385.00	现货
100mg	¥525.00	现货
200mg	¥840.00	现货
250mg	¥1,015.00	现货
500mg	¥1,330.00	现货
1g	¥2,030.00	现货
*10mM 1mL in DMSO**	¥448.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用AZD6244 (Selumetinib) 发表的1篇文献

Chia-Chi Chang, .et al. , Oncotarget, 2016, Jun 7; 7(23): 35270-35283 PMID: 27150057

生物活性

Discription

AZD6244 (Selumetinib) also known as Selumetinib, ARRY142886, AZD-6244 & ARRY-142886 is MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nm.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A10257
分子式	C17H15BrClFN4O3
分子量	457.7
CAS号	606143-52-6
SMILES	CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO
其他名称	ARRY-142886
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	Warmed: 80 mg/mL (174.79 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+30% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.85 mL	109.24 mL	218.48 mL
0.5 mM	4.37 mL	21.85 mL	43.7 mL
1 mM	2.18 mL	10.92 mL	21.85 mL
5 mM	0.44 mL	2.18 mL	4.37 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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