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AZD6482

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PI3K 抑制剂

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产品目录号: A10112

库存状态:中国现货中国现货

产品名 目录号 价格 数量
AZD6482 5mg A10112-5
¥ 900.00
AZD6482 10mg A10112-10
¥ 1,600.00
AZD6482 25mg A10112-25
¥ 3,500.00
AZD6482 50mg A10112-50
¥ 6,000.00
AZD6482 10mM * 1mL in DMSO A10112-10mM-D
¥ 1,330.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

AZD6482 is a PI3Kbeta inhibitor (IC50=0.021M) used in antithrombotic therapy.

AZD6482

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Chemical Information

目录号 A10112
Mechanism of action Inhibitor
分子量 408.5
化学分子式 C22H24N4O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1173900-33-8
Synonyms AZD-6482
SMILES code CC1=CN2C(=O)C=C(N=C2C(=C1)[C@@H](C)NC3=CC=CC=C3C(=O)O)N4CCOCC4
化学名称 2-[[(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid

生物活性

Description
AZD6482 is a PI3Kbeta inhibitor (IC50=0.021M) used in antithrombotic therapy.
Targets
PI3Kβ (Cell-free assay) PI3Kδ (Cell-free assay) DNA-PK (Cell-free assay) PI3Kα (Cell-free assay) PI3Kγ (Cell-free assay)
10 nM80 nM420 nM870 nM1090 nM

溶解性

Solubility (25°C) * In vitro DMSO 82 mg/mL (200.75 mM)
Water <1 mg/mL (<1 mM)
Ethanol 10 mg/mL (24.48 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.48 mL 122.4 mL 244.8mL
0.5 mM 4.9 mL 24.48 mL 48.96 mL
1 mM 2.45 mL 12.24 mL 24.48 mL
5 mM 0.49 mL 2.45 mL 4.9 mL

*The above data is based on the productmolecular weight 408.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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