AZD6738 (Ceralasertib)

Name: AZD6738 (Ceralasertib)
SKU: A15794
Price: 245 CNY
Rating: 5 (5 reviews)

目录号: A15794

ATR 抑制剂

5 篇发表文献

AZD6738 是一种强效的 ATR激酶 抑制剂，其对分离酶的 IC50 为1 nM，对细胞中 ATR激酶 依赖的 CHK1磷酸化 的 IC50 为74 nM。

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Grouped product items
规格	价格	库存
1mg	¥245.00	现货
5mg	¥630.00	现货
10mg	¥980.00	现货
25mg	¥2,065.00	现货
50mg	¥2,870.00	现货
100mg	¥5,460.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用AZD6738 (Ceralasertib)发表的5篇文献

Erika Nakatsuka, .et al. , Transl Oncol, 2024, Sep 12:50:102119 PMID: 39270525

Zhiyan Silvia Liu, .et al. , Cancer Res, 2024, Feb 15;84(4):577-597 PMID: 37967363

Yang Lim, .et al. , Science, 2023, Sep 22;381(6664) PMID: 37590370

Brian F Kiesel, .et al. , Cancer Chemother Pharmacol, 2022, Feb;89(2):231-242 PMID: 35066692

Albert Job, .et al. , Sci Rep, 2020, Nov 3;10(1):18924 PMID: 33144657

生物活性

Discription

AZD6738 is a potent inhibitor of ATR kinase activity with an IC50 of 1 nM against the isolated enzyme and 74 nM against ATR kinase-dependent CHK1 phosphorylation in cells.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A15794
分子式	C20H24N6O2S
分子量	412.51
CAS号	1352226-88-0
SMILES	C[C@H]1N(C2=NC(C3=C4C(NC=C4)=NC=C3)=NC(C5([S@](=O)(C)=N)CC5)=C2)CCOC1
其他名称	AZD-6738, AZD 6738
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	75 mg/mL (181.81 mM)
	Water	Insoluble
	Ethanol	Warmed: 38 mg/mL
In vivo	5% DMSO+40% propylene glycol+ddH2O	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.24 mL	121.21 mL	242.42 mL
0.5 mM	4.85 mL	24.24 mL	48.48 mL
1 mM	2.42 mL	12.12 mL	24.24 mL
5 mM	0.48 mL	2.42 mL	4.85 mL

Useful Calculator

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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