Trusted by 10,000+ Scientists since 2006
微信关注
申请试用装

AZD8055

促销

mTOR 抑制剂

0 Customer Reviews
产品目录号: A10114

库存状态:中国现货中国现货

产品名 目录号 价格 数量
AZD8055 10mg A10114-10
¥ 400.00
AZD8055 25mg A10114-25
¥ 800.00
AZD8055 50mg A10114-50
¥ 1,200.00
AZD8055 100mg A10114-100
¥ 1,800.00
AZD8055 10mM * 1mL in DMSO A10114-10mM-D
¥ 780.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM.

AZD8055

双击上述图片即可查看完整大小

缩小
放大

更多视图

顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 AZD8055 发表的文献 (2)
  • Helga Weber, .et al. Rapamycin and WYE-354 suppress human gallbladder cancer xenografts in mice, Oncotarget, 2015, Oct 13; 6(31): 31877每31888 PMID: 26397134
  • Kentaro Hirose, .et al. Mechanistic target of rapamycin complex 1 signaling regulates cell proliferation, cell survival, and differentiation in regenerating zebrafish fins, BMC Dev Biol, 2014, 14: 42. PMID: 25480380

Chemical Information

目录号 A10114
Mechanism of action Inhibitor
分子量 465.5
化学分子式 C25H31N5O4
Solubility DMSO>93mg/mL Water>2mg/mL Ethanol>15mg/mL
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1009298-09-2
Synonyms AZD-8055
SMILES code C[C@H]1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=C(C=C4)OC)CO)N5CCOC[C@@H]5C
化学名称 [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol

生物活性

Description
AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM.
Targets
Target Value
mTOR(truncated)IC50: 0.13nM
mTOR(fulllength)IC50: 0.8nM
DNA-PKIC50: 1370nM
PI3KδIC50: 3200nM
PI3KαIC50: 3590nM
ATMIC50: 7350nM
PI3KγIC50: >14790nM
PI3KβIC50: 18900nM

溶解性

Solubility (25°C)* In vitro DMSO 50 mg/mL heating (107.4 mM)
Water <1 mg/mL (<1 mM)
Ethanol 3 mg/mL (6.44 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.48 mL 107.41 mL 214.82mL
0.5 mM 4.3 mL 21.48 mL 42.96 mL
1 mM 2.15 mL 10.74 mL 21.48 mL
5 mM 0.43 mL 2.15 mL 4.3 mL

*The above data is based on the productmolecular weight 465.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Ordering online

To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.

To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.

When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards.  We will then liaise with you or your purchasing department to confirm the order.

Found your products but not ready to order?

Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.

Ordering offline

You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order.  Our contact details are:

We require the following information to process your order:
  • The catalog number for each product. 
  • Your email address or fax number. 
  • Your name and telephone number. 
  • Shipping address and billing address.
  • Purchase order numbers.

产品标签

使用空格分隔标签。使用单引号(')标注词组。


Keywords:购买 AZD8055 | AZD8055 供应商 | 订购 AZD8055 | AZD8055 价格 | AZD8055 生产商 | 订单 AZD8055 | AZD8055 代理商 | 购买 1009298-09-2| 1009298-09-2 供应商 | 订购 1009298-09-2 | 1009298-09-2 价格 | 1009298-09-2 生产商 | 订单 1009298-09-2 | 1009298-09-2 代理商|buy AZD8055 | AZD8055 Supplier | purchase AZD8055 | AZD8055 cost | AZD8055 manufacturer | order AZD8055 | AZD8055 distributor | buy 1009298-09-2| 1009298-09-2 Supplier | purchase 1009298-09-2 | 1009298-09-2 cost | 1009298-09-2 manufacturer | order 1009298-09-2 | 1009298-09-2 distributor