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mTOR 抑制剂

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产品目录号: A10114


产品名 目录号 价格 数量
AZD8055 10mg A10114-10
¥ 400.00
AZD8055 25mg A10114-25
¥ 800.00
AZD8055 50mg A10114-50
¥ 1,200.00
AZD8055 100mg A10114-100
¥ 1,800.00
AZD8055 10mM * 1mL in DMSO A10114-10mM-D
¥ 780.00



AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM.





顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 AZD8055 发表的文献 (2)
  • Helga Weber, .et al. Rapamycin and WYE-354 suppress human gallbladder cancer xenografts in mice, Oncotarget, 2015, Oct 13; 6(31): 31877每31888 PMID: 26397134
  • Kentaro Hirose, .et al. Mechanistic target of rapamycin complex 1 signaling regulates cell proliferation, cell survival, and differentiation in regenerating zebrafish fins, BMC Dev Biol, 2014, 14: 42. PMID: 25480380

Chemical Information

目录号 A10114
Mechanism of action Inhibitor
分子量 465.5
化学分子式 C25H31N5O4
Solubility DMSO>93mg/mL Water>2mg/mL Ethanol>15mg/mL
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1009298-09-2
Synonyms AZD-8055
化学名称 [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol


AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM.
Target Value
mTOR(truncated)IC50: 0.13nM
mTOR(fulllength)IC50: 0.8nM
DNA-PKIC50: 1370nM
PI3KδIC50: 3200nM
PI3KαIC50: 3590nM
ATMIC50: 7350nM
PI3KγIC50: >14790nM
PI3KβIC50: 18900nM


Solubility (25°C)* In vitro DMSO 50 mg/mL heating (107.4 mM)
Water <1 mg/mL (<1 mM)
Ethanol 3 mg/mL (6.44 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.48 mL 107.41 mL 214.82mL
0.5 mM 4.3 mL 21.48 mL 42.96 mL
1 mM 2.15 mL 10.74 mL 21.48 mL
5 mM 0.43 mL 2.15 mL 4.3 mL

*The above data is based on the productmolecular weight 465.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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