AZD8186
目录号: A15759
PI3K 抑制剂
AZD8186 是一种特异性小分子 PI3K 抑制剂，强效抑制 PI3Kβ (IC50=4 nM) 和 PI3Kδ (IC50=12 nM)，并且相对于 PI3Kα (IC50=35 nM) 和 PI3Kγ (IC50=675 nM) 具有选择性。
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生物活性
| Discription | AZD8186 is an isoform-specific small-molecule PI3K inhibitor, potently inhibits PI3Kβ (IC50=4 nM) and PI3Kδ (IC50=12 nM) with selectivity over PI3Kα (IC50=35 nM) and PI3Kγ (IC50=675 nM). | |||||
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产品信息
| 目录号 | A15759 |
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| 分子式 | C24H25F2N3O4 |
| 分子量 | 457.47 |
| CAS号 | 1627494-13-6 |
| SMILES | CC(C1=C2C(=CC(=C1)C(=O)N(C)C)C(=O)C=C(O2)N3CCOCC3)NC4=CC(=CC(=C4)F)F |
| 其他名称 | AZD 8186, AZD-8186 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro (25°C) | DMSO | Warmed: 82 mg/mL (179.25 mM) | |
| Water | Insoluble | ||
| Ethanol | Warmed: 32 mg/mL (69.94 mM) | ||
| In vivo | 10% DMSO + 60% TEG+ 30% WFI | 15 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.86 mL | 109.3 mL | 218.59 mL |
| 0.5 mM | 4.37 mL | 21.86 mL | 43.72 mL |
| 1 mM | 2.19 mL | 10.93 mL | 21.86 mL |
| 5 mM | 0.44 mL | 2.19 mL | 4.37 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 1627494-13-6 | 1627494-13-6 供应商 | 1627494-13-6 花费 | 1627494-13-6 生产商 | 订购 1627494-13-6 | 1627494-13-6 代理商