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MEK 抑制剂

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产品目录号: A10115


产品名 目录号 价格 数量
AZD8330 5mg A10115-5
¥ 1,100.00
AZD8330 10mg A10115-10
¥ 2,000.00
AZD8330 50mg A10115-50
¥ 6,200.00
AZD8330 100mg A10115-100
¥ 10,800.00
AZD8330 10mM * 1mL in DMSO A10115-10mM-D
¥ 1,600.00



AZD8330 is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.





顾客使用 Adooq 产品发表的高质量科研文献

Chemical Information

目录号 A10115
Mechanism of action Inhibitor
分子量 461.2
化学分子式 C16H17FIN3O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 869357-68-6
Synonyms AZD-8330
化学名称 2-(2-Fluoro-4-iodophenylamino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide


AZD8330 is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.
ERK phosphorylation MEK1/2
0.4 nM7 nM


Solubility (25°C) * In vitro DMSO 92 mg/mL (199.46 mM)
Water <1 mg/mL (<1 mM)
Ethanol 92 mg/mL (199.46 mM)
In vivo 0.5% hydroxyethyl cellulose/0.1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.68 mL 108.41 mL 216.83mL
0.5 mM 4.34 mL 21.68 mL 43.37 mL
1 mM 2.17 mL 10.84 mL 21.68 mL
5 mM 0.43 mL 2.17 mL 4.34 mL

*The above data is based on the productmolecular weight 461.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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