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AZD8835

PI3K??/PI3K?? 抑制剂

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产品目录号: A16352

库存状态:中国现货中国现货

产品名 目录号 价格 数量
AZD8835 5mg A16352-5
¥ 900.00
AZD8835 10mg A16352-10
¥ 1,600.00
AZD8835 50mg A16352-50
¥ 4,800.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

AZD8835 is a potent and selective inhibitor of PI3Kα and PI3Kδ with IC50 of 5.7 nM and 6.2 nM, with selectivity against PI3Kβ (IC50 431 nM) and PI3Kγ (IC50 90 nM).

AZD8835

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Chemical Information

目录号 A16352
Mechanism of action Inhibitor
分子量 469.54
化学分子式 C22H31N9O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1620576-64-8
Synonyms AZD 8835, AZD-8835
SMILES code O=C(N1CCC(C2=NN(CC)C(C3=NC(C4=NN=C(C(C)(C)C)O4)=C(N)N=C3)=N2)CC1)CCO
化学名称 1-(4-(5-(5-amino-6-(5-(tert-butyl)-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1H-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one

生物活性

Description
AZD8835 is a potent and selective inhibitor of PI3Kα and PI3Kδ with IC50 of 5.7 nM and 6.2 nM, with selectivity against PI3Kβ (IC50 431 nM) and PI3Kγ (IC50 90 nM).

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.3 mL 106.49 mL 212.97mL
0.5 mM 4.26 mL 21.3 mL 42.59 mL
1 mM 2.13 mL 10.65 mL 21.3 mL
5 mM 0.43 mL 2.13 mL 4.26 mL

*The above data is based on the productmolecular weight 469.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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