AZD8931 (Sapitinib)

目录号: A10116

pan-EGFR/pan-erbB inhibitor

AZD8931 (Sapitinib)

AZD8931 (Sapitinib) Chemical Structure

CAS NO. 848942-61-0

AZD8931 is an oral, equipotent inhibitor of ErbB1, ErbB2 and ErbB3 receptor signaling.

库存: 现货

规格 价格 数量
5 mg
¥ 900.00
10 mg
¥ 1,700.00
25 mg
¥ 3,500.00
100 mg
¥ 9,500.00
10mM * 1mL in DMSO
¥ 1,000.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

AZD8931 is an oral, equipotent inhibitor of ErbB1, ErbB2 and ErbB3 receptor signaling.
Targets
ErbB2 (Cell-free assay) EGFR (Cell-free assay) ErbB3 (Cell-free assay)
3 nM4 nM4 nM
In vitro (25°C) DMSO 40 mg/mL (84.4 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.1 mL 105.51 mL 211.01 mL
0.5 mM 4.22 mL 21.1 mL 42.2 mL
1 mM 2.11 mL 10.55 mL 21.1 mL
5 mM 0.42 mL 2.11 mL 4.22 mL

*The above data is based on the productmolecular weight 473.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

目录号 A10116
MECHANISM OF ACTION Inhibitor
M. Wt 473.9
Formula C23H25ClFN5O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 848942-61-0
Synonyms AZD-8931, Momelotinib, Sapitinib
SMILES CNC(=O)CN1CCC(CC1)OC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C(=CC=C4)Cl)F)OC

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