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B-Raf inhibitor 1是有效的选择性B-Raf抑制剂，对A375增殖和A375 p-ERK的细胞IC50分别为0.31 uM和2 nM。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.88 mL | 104.4 mL | 208.79 mL |
| 0.5 mM | 4.18 mL | 20.88 mL | 41.76 mL |
| 1 mM | 2.09 mL | 10.44 mL | 20.88 mL |
| 5 mM | 0.42 mL | 2.09 mL | 4.18 mL |
*The above data is based on the productmolecular weight 478.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A14122 |
|---|---|
| MECHANISM OF ACTION | Inhibitor |
| M. Wt | 478.94 |
| Formula | C26H19ClN8 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1093100-40-3 |
| Synonyms | B-Raf inhibitor1, B-Raf inhibitor-1 |
| SMILES | CC1=C(C2=C(C=C1)C(=NC=C2)NC3=CC=C(C=C3)Cl)NC4=C(C=CC=N4)C5=C6C(=NC=N5)N=CN6 |
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