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Bafetinib (INNO-406)


Bcr-Abl 抑制剂

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产品目录号: A10119


产品名 目录号 价格 数量
Bafetinib 5mg A10119-5
¥ 750.00
Bafetinib 10mg A10119-10
¥ 1,300.00
Bafetinib 50mg A10119-50
¥ 3,900.00
Bafetinib 100mg A10119-100
¥ 4,800.00
Bafetinib (INNO-406) 10mM * 1mL in DMSO A10119-10mM-D
¥ 1,740.00



Bafetinib ((INNO-406) is a dual Bcr-Abl/Lyn tyrosine kinase inhibitor for the potential treatment of leukemia.

Bafetinib (INNO-406)




顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Bafetinib (INNO-406) 发表的文献 (4)
  • Li T, .et al. Bruton's tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma, Oncogene, 2018, Nov;37(47):6180-6194 PMID: 30013190
  • S. Dallari, .et al. Src family kinases Fyn and Lyn are constitutively activated and mediate plasmacytoid dendritic cell responses, Nat Commun, 2017, 8: 14830 PMID: 28368000
  • Andrea Haerzschel, .et al. BCR and chemokine responses upon anti-IgM and anti-IgD stimulation in chronic lymphocytic leukaemia, Ann Hematol, 2016, 95(12): 1979每1988 PMID: 27542958
  • Magdalena Winiarska, .et al. Inhibitors of SRC kinases impair antitumor activity of anti-CD20 monoclonal antibodies, MAbs., 2014, 6(5): 1300每1313. PMID: 25517315

Chemical Information

目录号 A10119
Mechanism of action Inhibitor
分子量 576.6
化学分子式 C30H31F3N8O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 859212-16-1
Synonyms NS-187
SMILES code CC1=C(C=C(C=C1)NC(=O)C2=CC(=C(C=C2)CN3CC[C@@H](C3)N(C)C)C(F)(F)F)NC4=NC=CC(=N4)C5=CN=CN=C5
化学名称 N-[3-([5,5'-Bipyrimidin]-2-ylamino)-4-methylphenyl]-4-[[(3S)-3-(dimethylamino)-1-pyrrolidinyl]methyl]-3-(trifluoromethyl)benzamide


Bafetinib ((INNO-406) is a dual Bcr-Abl/Lyn tyrosine kinase inhibitor for the potential treatment of leukemia.
Abl (Cell-free assay) Lyn (Cell-free assay)
5.8 nM19 nM


Solubility (25°C) * In vitro DMSO 100 mg/mL (173.42 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.34 mL 86.72 mL 173.43mL
0.5 mM 3.47 mL 17.34 mL 34.69 mL
1 mM 1.73 mL 8.67 mL 17.34 mL
5 mM 0.35 mL 1.73 mL 3.47 mL

*The above data is based on the productmolecular weight 576.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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