Bardoxolone methyl (RTA 402)

目录号: A11323

IκB/IKK inhibitor

Bardoxolone methyl (RTA 402) Chemical Structure

CAS NO. 218600-53-4

Bardoxolone methyl is an orally-available first-in-class synthetic triterpenoid. It is an inducer of the Nrf2 pathway, which can suppress oxidative stress and inflammation.

库存: 现货

规格 价格 数量
25 mg
¥ 600.00
50 mg
¥ 900.00
100 mg
¥ 1,350.00
200 mg
¥ 2,250.00
10mM * 1mL in DMSO
¥ 600.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

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Bardoxolone methyl is an orally-available first-in-class synthetic triterpenoid. It is an inducer of the Nrf2 pathway, which can suppress oxidative stress and inflammation.
Targets
IKK (Cell-free assay)
In vitro (25°C) DMSO 21 mg/mL (41.52 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.77 mL 98.87 mL 197.75 mL
0.5 mM 3.95 mL 19.77 mL 39.55 mL
1 mM 1.98 mL 9.89 mL 19.77 mL
5 mM 0.4 mL 1.98 mL 3.95 mL

*The above data is based on the productmolecular weight 505.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11323
MECHANISM OF ACTION Inhibitor
M. Wt 505.7
Formula C32H43NO4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 218600-53-4
Synonyms NSC 713200, CDDO-methyl ester
SMILES C[C@@]12CC[C@]3(CCC(C[C@H]3[C@H]1C(=O)C=C4[C@]2(CC[C@@H]5[C@@]4(C=C(C(=O)C5(C)C)C#N)C)C)(C)C)C(=O)OC

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