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Bardoxolone methyl (RTA 402)

促销

I??B/IKK 抑制剂

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产品目录号: A11323

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Bardoxolone methyl 25mg A11323-25
¥ 900.00
Bardoxolone methyl 50mg A11323-50
¥ 1,600.00
Bardoxolone methyl 100mg A11323-100
¥ 2,800.00
Bardoxolone methyl 200mg A11323-200
¥ 4,500.00
Bardoxolone methyl (RTA 402) 10mM * 1mL in DMSO A11323-10mM-D
¥ 770.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Bardoxolone methyl is an orally-available first-in-class synthetic triterpenoid. It is an inducer of the Nrf2 pathway, which can suppress oxidative stress and inflammation.

Bardoxolone methyl (RTA 402)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Bardoxolone methyl (RTA 402) 发表的文献 (3)
  • Hisamichi M, .et al. Role of bardoxolone methyl, a nuclear factor erythroid 2-related factor 2 activator, in aldosterone- and salt-induced renal injury, Hypertens Res, 2018, Jan;41(1):8-17 PMID: 28978980
  • Takahiko Imai, .et al. Nrf2 activator ameliorates hemorrhagic transformation in focal cerebral ischemia under warfarin anticoagulation, Neurobiol Dis, 2016, May;89:136-46 PMID: 26850917
  • Takagi T, .et al. Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia-reperfusion injury., Free Radic Biol Med., 2014, 72:124-33 PMID: 24746614

Chemical Information

目录号 A11323
Mechanism of action Inhibitor
分子量 505.7
化学分子式 C32H43NO4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 218600-53-4
Synonyms NSC 713200, CDDO-methyl ester
SMILES code C[C@@]12CC[C@]3(CCC(C[C@H]3[C@H]1C(=O)C=C4[C@]2(CC[C@@H]5[C@@]4(C=C(C(=O)C5(C)C)C#N)C)C)(C)C)C(=O)OC
化学名称 Methyl 2-cyano-3,12-dioxooleana-1,9(11)dien-28-oate

生物活性

Description
Bardoxolone methyl is an orally-available first-in-class synthetic triterpenoid. It is an inducer of the Nrf2 pathway, which can suppress oxidative stress and inflammation.
Targets
IKK (Cell-free assay)

溶解性

Solubility (25°C) * In vitro DMSO 21 mg/mL (41.52 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.77 mL 98.87 mL 197.75mL
0.5 mM 3.95 mL 19.77 mL 39.55 mL
1 mM 1.98 mL 9.89 mL 19.77 mL
5 mM 0.4 mL 1.98 mL 3.95 mL

*The above data is based on the productmolecular weight 505.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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