Baricitinib (LY3009104)

目录号: A11329

JAK 抑制剂

Baricitinib (LY3009104)

Baricitinib (LY3009104) Chemical Structure

CAS NO. 1187594-09-7

Baricitinib,也称为INCB028050或LY3009104,是一种选择性口服可生物利用的JAK1/JAK2抑制剂,对JAK1(5.9 nM)和JAK2(5.7 nM)具有纳摩尔浓度。

库存: 现货

规格 价格 数量
5 mg
¥ 600.00
10 mg
¥ 700.00
25 mg
¥ 900.00
50 mg
¥ 1,200.00
10mM * 1mL in DMSO
¥ 600.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

Baricitinib,也称为INCB028050或LY3009104,是一种选择性口服可生物利用的JAK1/JAK2抑制剂,对JAK1(5.9 nM)和JAK2(5.7 nM)具有纳摩尔浓度。
Targets
Target Value
JAK2IC50: 5.7nM
JAK1IC50: 5.9nM
TYK2IC50: 53nM
JAK3IC50: >400nM
Chk2IC50: >1μM
c-MetIC50: >10μM
In vitro (25°C) DMSO 65 mg/mL (175 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.93 mL 134.63 mL 269.25 mL
0.5 mM 5.39 mL 26.93 mL 53.85 mL
1 mM 2.69 mL 13.46 mL 26.93 mL
5 mM 0.54 mL 2.69 mL 5.39 mL

*The above data is based on the productmolecular weight 371.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11329
作用机制 Inhibitor (抑制剂)
M. Wt 371.4
Formula C16H17N7O2S
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 1187594-09-7
Synonyms INCB28050, LY3009104
SMILES CCS(=O)(=O)N1CC(C1)(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3

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