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Bay 11-7821

促销

E2 ubiquitin conjugating enzyme 抑制剂

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产品目录号: A11957

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Bay 11-7821 10mg A11957-10
¥ 500.00
Bay 11-7821 25mg A11957-25
¥ 900.00
Bay 11-7821 50mg A11957-50
¥ 1,600.00
Bay 11-7821 100mg A11957-100
¥ 2,800.00
Bay 11-7821 10mM * 1mL in DMSO A11957-10mM-D
¥ 690.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Bay 11-7821 is an irreversible inhibitor of TNF-α-stimulated IκBα phosphorylation.

Bay 11-7821

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Bay 11-7821 发表的文献 (1)
  • Momeny M, .et al. Blockade of nuclear factor-百B (NF-百B) pathway inhibits growth and induces apoptosis in chemoresistant ovarian carcinoma cells, Int J Biochem Cell Biol, 2018, Jun;99:1-9 PMID: 29567488

Chemical Information

目录号 A11957
Mechanism of action Inhibitor
分子量 207.25
化学分子式 C10H9NO2S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 19542-67-7
Synonyms Bay-11-7821, Bay 117821, Bay117821, Bay117082, Bay-11-7082, Bay 117082
SMILES code CC1=CC=C(C=C1)S(=O)(=O)/C=C/C#N
化学名称 (2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile

生物活性

Description
Bay 11-7821 is an irreversible inhibitor of TNF-α-stimulated IκBα phosphorylation.
Targets
E2-conjugating enzymes (Cell-free assay) IκBα?phosphorylation (Tumor cells)
N/A10 μM

溶解性

Solubility (25°C) * In vitro DMSO 41 mg/mL (197.82 mM)
Water <1 mg/mL (<1 mM)
Ethanol 10 mg/mL (48.25 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 48.25 mL 241.25 mL 482.51mL
0.5 mM 9.65 mL 48.25 mL 96.5 mL
1 mM 4.83 mL 24.13 mL 48.25 mL
5 mM 0.97 mL 4.83 mL 9.65 mL

*The above data is based on the productmolecular weight 207.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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