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Bcl-2 Inhibitor

Bcl-2 抑制剂

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产品目录号: A13580

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Bcl-2 Inhibitor 5mg A13580-5
¥ 3,500.00
Bcl-2 Inhibitor 10mg A13580-10
¥ 6,000.00
Bcl-2 Inhibitor 25mg A13580-25
¥ 12,500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Bcl-2 Inhibitor contains a mixture of two tautomers. A potent, cell-permeable, Bcl-2 inhibitor competes with Bak BH3 peptide for binding to Bcl-2 and Bcl-XL in vitro (IC50 =10 uM and 7 uM, respectively).

Bcl-2 Inhibitor

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Bcl-2 Inhibitor 发表的文献 (1)
  • Toshiyuki Sumi, .et al. Survivin knockdown induces senescence in TTF-1-expressing, KRAS-mutant lung adenocarcinomas, Int J Oncol, 2018, Jul; 53(1): 33每46 PMID: 29658609

Chemical Information

目录号 A13580
Mechanism of action Inhibitor
分子量 300.3
化学分子式 C16H16N2O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 383860-03-5
Synonyms TW-37
SMILES code COC1=CC(=C(C=C1)N=O)CCC2=C(C=CC(=C2)OC)N=O
化学名称 N-[4-[[2-(1,1-DIMETHYLETHYL)PHENYL]SULFONYL]PHENYL]-2,3,4-TRIHYDROXY-5-[[2-(1-METHYLETHYL)PHENYL]METHYL]BENZAMIDE

生物活性

Description
Bcl-2 Inhibitor contains a mixture of two tautomers. A potent, cell-permeable, Bcl-2 inhibitor competes with Bak BH3 peptide for binding to Bcl-2 and Bcl-XL in vitro (IC50 =10 uM and 7 uM, respectively).

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 33.3 mL 166.5 mL 333mL
0.5 mM 6.66 mL 33.3 mL 66.6 mL
1 mM 3.33 mL 16.65 mL 33.3 mL
5 mM 0.67 mL 3.33 mL 6.66 mL

*The above data is based on the productmolecular weight 300.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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