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BDTX-189 is a potent, orally active and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations, including EGFR/HER2 exon 20 insertion mutants. BDTX-189 shows KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively. Anticancer activity.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.82 mL | 89.12 mL | 178.24 mL |
| 0.5 mM | 3.56 mL | 17.82 mL | 35.65 mL |
| 1 mM | 1.78 mL | 8.91 mL | 17.82 mL |
| 5 mM | 0.36 mL | 1.78 mL | 3.56 mL |
*The above data is based on the productmolecular weight 561.03. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A22306 |
|---|---|
| M. Wt | 561.03 |
| Formula | C29H29ClN6O4 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 2 years |
| CAS No. | 2414572-47-5 |
| SMILES | C=CC(NC1=CC2=C(NC3=CC=C(OCC4=NC=CC=C4)C(Cl)=C3)N=CN=C2C=C1OCCN5CCOCC5)=O |
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