Belvarafenib

Name: Belvarafenib
SKU: A13177
Price: 175 CNY
Rating: 5 (288 reviews)

目录号: A13177

pan RAF 抑制剂

Belvarafenib (HM95573) 是一种强效的全面 RAF (Rapidly Accelerated Fibrosarcoma) 抑制剂，其半抑制浓度（IC50）分别为对 B-RAF 为 56 nM、对 B-RAFv600E 为 7 nM、对 C-RAF 为 5 nM。

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Grouped product items
规格	价格	库存
2mg	¥175.00	现货
5mg	¥350.00	现货
10mg	¥665.00	现货
25mg	¥1,155.00	现货
50mg	¥1,750.00	现货
100mg	¥2,625.00	现货
*10mM 1mL in DMSO**	¥350.00	现货
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Data Sheet

SDS

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生物活性

Discription

Belvarafenib (HM95573) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.

Targets

Target	Value

产品信息

目录号	A13177
分子式	C23H16ClFN6OS
分子量	478.93
CAS号	1446113-23-0
SMILES	O=C(C(C1=NC=N2)=CSC1=C2N)NC(C3=C4C(NC(C=CC=C5Cl)=C5F)=NC=C3)=C(C=C4)C
其他名称	HM 95573, HM-95573, HM95573; GDC-5573, GDC5573, GDC 5573; RG6185, RG 6185, RG-6185
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	84 mg/mL (175.39 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.88 mL	104.4 mL	208.8 mL
0.5 mM	4.18 mL	20.88 mL	41.76 mL
1 mM	2.09 mL	10.44 mL	20.88 mL
5 mM	0.42 mL	2.09 mL	4.18 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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