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Belvarafenib

Belvarafenib

Name: Belvarafenib
SKU: A13177

目录号: A13177

pan RAF inhibitor

Belvarafenib Chemical Structure

CAS NO. 1446113-23-0

Belvarafenib (HM95573) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.

库存：现货

规格	价格	数量
5 mg	￥ 1,620.00
10 mg	￥ 2,790.00
50 mg	￥ 8,280.00

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产品仅用于科学研究，不针对患者销售，望谅解.

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生物活性

Belvarafenib (HM95573) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.

溶解度 *

In vitro	DMSO	84 mg/mL (175.39 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.88 mL	104.4 mL	208.8 mL
0.5 mM	4.18 mL	20.88 mL	41.76 mL
1 mM	2.09 mL	10.44 mL	20.88 mL
5 mM	0.42 mL	2.09 mL	4.18 mL

*The above data is based on the productmolecular weight 478.93. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A13177
作用机制	Inhibitor (抑制剂)
M. Wt	478.93
Formula	C23H16ClFN6OS
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1446113-23-0
Synonyms	HM 95573, HM-95573, HM95573; GDC-5573, GDC5573, GDC 5573; RG6185, RG 6185, RG-6185
SMILES	O=C(C(C1=NC=N2)=CSC1=C2N)NC(C3=C4C(NC(C=CC=C5Cl)=C5F)=NC=C3)=C(C=C4)C