|Mechanism of action||否|
|储存方式||at -20°C 2 years|
|Synonyms||Ribomustin, Treanda, SDX-105, Treakisym|
|化学名称||4-[5-[Bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid hydrochloride|
Bendamustine Hydrochloride is a small molecule bifunctional DNA alkylating agent, combining a nitrogen mustard functionality with a purine-analog structure. The dense DNA-damaging functionality of Bendamustine differentiates it from other compounds used as antiproliferative agents, and these functionalities are thought to promote cell death through a variety of different pathways including apoptosis and mitotic catastrophe.
|Solubility (25°C) *||In vitro||DMSO||79 mg/mL (200.14 mM)|
|Water||15 mg/mL (38 mM)|
|Ethanol||17 mg/mL (43.06 mM)|
|In vivo||1% DMSO/30% polyethylene glycol/1% Tween 80||30 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||25.34 mL||126.68 mL||253.36mL|
|0.5 mM||5.07 mL||25.34 mL||50.67 mL|
|1 mM||2.53 mL||12.67 mL||25.34 mL|
|5 mM||0.51 mL||2.53 mL||5.07 mL|
*The above data is based on the productmolecular weight 394.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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