Benufutamab (GEN1029) is an agonistic antibody targeting death receptor 5 (DR5), designed to selectively initiate apoptosis in tumor cells. This biologic is composed of two non-competing, DR5-specific IgG1 antibodies, each engineered with an E430G mutation in the Fc domain to enhance its therapeutic efficacy. Benufutamab demonstrates significant antitumor activity, making it a valuable tool for research in cancer therapy and apoptosis mechanisms.
Benufutamab (GEN1029) is an agonistic antibody targeting death receptor 5 (DR5), designed to selectively initiate apoptosis in tumor cells. This biologic is composed of two non-competing, DR5-specific IgG1 antibodies, each engineered with an E430G mutation in the Fc domain to enhance its therapeutic efficacy. Benufutamab demonstrates significant antitumor activity, making it a valuable tool for research in cancer therapy and apoptosis mechanisms.
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