BEZ235 (NVP-BEZ235, Dactolisib)

Name: BEZ235 (NVP-BEZ235, Dactolisib)
SKU: A10133
Price: 175 CNY
Rating: 5 (4 reviews)

目录号: A10133

PI3K/mTOR 抑制剂

4 篇发表文献

BEZ235（NVP-BEZ235）通过结合到这些酶的ATP结合裂隙，抑制PI3K和mTOR激酶活性。

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Grouped product items
规格	价格	库存
25mg	¥175.00	现货
50mg	¥315.00	现货
100mg	¥385.00	现货
200mg	¥700.00	现货
500mg	¥1,680.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

Other Forms of BEZ235 (NVP-BEZ235, Dactolisib)

Dactolisib Tosylate

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用BEZ235 (NVP-BEZ235, Dactolisib)发表的4篇文献

Lijuan Chen, .et al. , Behav Neurol, 2023, May 9;2023:6991826 PMID: 37200987

Makoto Koyama, .et al. , Int J Oncol, 2020, Sep 2 PMID: 32901840

Tzeng SF, .et al. , FASEB J, 2018, Jun 15:fj201800687 PMID: 29906246

Dominik Schulz, .et al. , Am J Cancer Res, 2016, 6(9): 1963-1975 PMID: 27725902

生物活性

Discription

BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A10133
分子式	C30H23N5O
分子量	469.6
CAS号	915019-65-7
SMILES	CC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3N(C2=O)C)C5=CC6=CC=CC=C6N=C5
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	<1 mg/mL
	Water	Insoluble
	Ethanol	Warmed: 16 mg/mL (34.07 mM)
In vivo	NMP+PEG300 (10+90, v+v)	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.29 mL	106.47 mL	212.95 mL
0.5 mM	4.26 mL	21.29 mL	42.59 mL
1 mM	2.13 mL	10.65 mL	21.29 mL
5 mM	0.43 mL	2.13 mL	4.26 mL

Useful Calculator

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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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