BI-D1870

Name: BI-D1870
SKU: A12452
Price: 280 CNY
Rating: 5 (1 reviews)

目录号: A12452

S6 Kinase 抑制剂

1 篇发表文献

BI-D1870 是一种强效且特异性的 p90 核糖体 S6 激酶 (RSK) 各种异构体的抑制剂，可在体外和体内发挥作用，其对 RSK1、RSK2、RSK3 和 RSK4 的体外抑制浓度中值 (IC50) 为 10-30 nM。

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Grouped product items
规格	价格	库存
1mg	¥280.00	现货
2mg	¥455.00	现货
5mg	¥735.00	现货
10mg	¥1,295.00	现货
25mg	¥2,345.00	现货
50mg	¥3,430.00	现货
100mg	¥4,795.00	现货
500mg	¥10,115.00	现货
*10mM 1mL in DMSO**	¥735.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用BI-D1870发表的1篇文献

Yuan Xiao Zhu, etc. RNA interference screening identifies lenalidomide sensitizers in multiple myeloma, including RSK2. Blood. 2015 Jan 15; 125(3): 483?€?491.

生物活性

Discription

BI-D1870 is a potent and specific inhibitor of the p90 ribosomal S6 kinase (RSK) isoforms in vitro and in vivo, which inhibits RSK1, RSK2, RSK3 and RSK4 in vitro with an IC50 of 10?€?30 nM.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A12452
分子式	C19H23F2N5O2
分子量	391.41
CAS号	501437-28-1
SMILES	CC1C(=O)N(C2=CN=C(N=C2N1CCC(C)C)NC3=CC(=C(C(=C3)F)O)F)C
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	71 mg/mL (181.39 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.55 mL	127.74 mL	255.49 mL
0.5 mM	5.11 mL	25.55 mL	51.1 mL
1 mM	2.55 mL	12.77 mL	25.55 mL
5 mM	0.51 mL	2.55 mL	5.11 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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