- Hosoi T, .et al. Inhibition of telomerase causes vulnerability to endoplasmic reticulum stress-induced neuronal cell death, Neurosci Lett, 2016, Aug 26;629:241-244 PMID: 27443785
|Mechanism of action||Inhibitor|
|储存方式||at -20°C 2 years|
|化学名称||2-[[(2E)-3-(2-Naphthalenyl)-1-oxo-2 -butenyl1-yl]amino]benzoic acid|
BIBR 1532 is a selective telomerase inhibitor (IC50 values are 93, > 100000 and > 100000 nM for human telomerase, human RNA polymerase I and human RNA polymerase II + III respectively).
|Solubility (25°C) *||In vitro||DMSO||66 mg/mL (199.17 mM)|
|Water||<1 mg/mL (<1 mM)|
|Ethanol||3 mg/mL (9.05 mM)|
|In vivo||30% PEG400/0.5% Tween80/5% propylene glycol||30 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||30.18 mL||150.88 mL||301.75mL|
|0.5 mM||6.04 mL||30.18 mL||60.35 mL|
|1 mM||3.02 mL||15.09 mL||30.18 mL|
|5 mM||0.6 mL||3.02 mL||6.04 mL|
*The above data is based on the productmolecular weight 331.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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