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BIBR 953 (Dabigatran, Pradaxa)

促销

Thrombin 抑制剂

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产品目录号: A10138

库存状态:中国现货中国现货

产品名 目录号 价格 数量
BIBR 953 5mg A10138-5
¥ 800.00
BIBR 953 10mg A10138-10
¥ 1,400.00
BIBR 953 50mg A10138-50
¥ 4,500.00
BIBR 953 100mg A10138-100
¥ 7,200.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

BIBR 953 (Dabigatran, Pradaxa) is a highly selective, reversible, and potent thrombin inhibitor and is orally available as the prodrug, dabigatran etexilate. It has shown antithrombotic efficacy in animal models of thrombosis, with a rapid onset of action and predictable pharmacodynamic response.

BIBR 953 (Dabigatran, Pradaxa)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 BIBR 953 (Dabigatran, Pradaxa) 发表的文献 (1)
  • Tanaka M, .et al. Protease-activated receptor-1 negatively regulates proliferation of neural stem/progenitor cells derived from the hippocampal dentate gyrus of the adult mouse, J Pharmacol Sci, 2016, Jul;131(3):162-71 PMID: 27426918

Chemical Information

目录号 A10138
Mechanism of action Inhibitor
分子量 471.5
化学分子式 C25H25N7O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 211914-51-1
Synonyms BIBR-953, BIBR953
SMILES code CN1C2=C(C=C(C=C2)C(=O)N(CCC(=O)O)C3=CC=CC=N3)N=C1CNC4=CC=C(C=C4)C(=N)N
化学名称 3-[[2-[[(4-carbamimidoylphenyl)amino]methyl]-1-methyl-benzoimidazole-5-carbonyl]-pyridin-2-yl-amino]propanoic acid

生物活性

Description

BIBR 953 (Dabigatran, Pradaxa) is a highly selective, reversible, and potent thrombin inhibitor and is orally available as the prodrug, dabigatran etexilate. It has shown antithrombotic efficacy in animal models of thrombosis, with a rapid onset of action and predictable pharmacodynamic response.

Targets
Thrombin (Cell-free assay)
9.3 nM

溶解性

Solubility (25°C)* In vitro DMSO 0.5 mg/mL (1.06 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.21 mL 106.04 mL 212.09mL
0.5 mM 4.24 mL 21.21 mL 42.42 mL
1 mM 2.12 mL 10.6 mL 21.21 mL
5 mM 0.42 mL 2.12 mL 4.24 mL

*The above data is based on the productmolecular weight 471.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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