Bimagrumab is a human monoclonal antibody designed to inhibit the activin type II receptor (ActRII), demonstrating high affinity with dissociation constants (KDs) of 1.7 pM for ActRIIB and 434 pM for ActRIIA. This specificity suggests its utility in investigating the mechanisms underlying pathological muscle loss and weakness. Bimagrumab serves as an essential tool for research focused on muscle degenerative diseases by targeting and modulating the signaling pathways involved in muscle growth and repair.
Bimagrumab is a human monoclonal antibody designed to inhibit the activin type II receptor (ActRII), demonstrating high affinity with dissociation constants (KDs) of 1.7 pM for ActRIIB and 434 pM for ActRIIA. This specificity suggests its utility in investigating the mechanisms underlying pathological muscle loss and weakness. Bimagrumab serves as an essential tool for research focused on muscle degenerative diseases by targeting and modulating the signaling pathways involved in muscle growth and repair.
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