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Birinapant (TL32711)

促销

XIAP/cIAP1 拮抗剂

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产品目录号: A12738

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Birinapant (TL32711) 5mg A12738-5
¥ 700.00
Birinapant (TL32711) 10mg A12738-10
¥ 1,200.00
Birinapant (TL32711) 25mg A12738-25
¥ 2,000.00
Birinapant (TL32711) 50mg A12738-50
¥ 2,800.00
Birinapant (TL32711) 10mM * 1mL in DMSO A12738-10mM-D
¥ 1,000.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity.

Birinapant (TL32711)

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Chemical Information

目录号 A12738
Mechanism of action Antagonist
分子量 806.94
化学分子式 C42H56F2N8O6
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1260251-31-7
Synonyms TL-32711, TL 32711
SMILES code CC[C@@H](C(=O)N1C[C@H](C[C@H]1CC2=C(NC3=C2C=CC(=C3)F)C4=C(C5=C(N4)C=C(C=C5)F)C[C@@H]6C[C@@H](CN6C(=O)[C@H](CC)NC(=O)[C@H](C)NC)O)O)NC(=O)[C@H](C)NC
化学名称 (2S,2'S)-N,N'-((2S,2'S)-((3S,3'S,5R,5'R)-5,5'-((6,6'-difluoro-1H,1'H-[2,2'-biindole]-3,3'-diyl)bis(methylene))bis(3-hydroxypyrrolidine-5,1-diyl))bis(1-oxobutane-2,1-diyl))bis(2-(methylamino)propanamide)

生物活性

Description
Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity.
Targets
cIAP1 (Cell-free assay) XIAP (Cell-free assay)
<1 nM(Kd)45 nM(Kd)

溶解性

Solubility (25°C) * In vitro DMSO 100 mg/mL (123.92 mM)
Water <1 mg/mL (<1 mM)
Ethanol 55 mg/mL (68.15 mM)
In vivo 15% Captisol 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 12.39 mL 61.96 mL 123.92mL
0.5 mM 2.48 mL 12.39 mL 24.78 mL
1 mM 1.24 mL 6.2 mL 12.39 mL
5 mM 0.25 mL 1.24 mL 2.48 mL

*The above data is based on the productmolecular weight 806.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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