Birinapant (TL32711)

目录号: A12738

XIAP/cIAP1 antagonist

Birinapant (TL32711) Chemical Structure

CAS NO. 1260251-31-7

Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity.

库存: 现货

规格 价格 数量
5 mg
¥ 700.00
10 mg
¥ 1,200.00
25 mg
¥ 2,000.00
50 mg
¥ 2,800.00
10mM * 1mL in DMSO
¥ 1,000.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity.
靶点信息
cIAP1 (Cell-free assay) XIAP (Cell-free assay)
<1 nM(Kd)45 nM(Kd)
In vitro (25°C) DMSO 100 mg/mL (123.92 mM)
Water <1 mg/mL (<1 mM)
Ethanol 55 mg/mL (68.15 mM)
In vivo 15% Captisol 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 12.39 mL 61.96 mL 123.92 mL
0.5 mM 2.48 mL 12.39 mL 24.78 mL
1 mM 1.24 mL 6.2 mL 12.39 mL
5 mM 0.25 mL 1.24 mL 2.48 mL

*The above data is based on the productmolecular weight 806.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A12738
MECHANISM OF ACTION Antagonist
M. Wt 806.94
Formula C42H56F2N8O6
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1260251-31-7
Synonyms TL-32711, TL 32711
SMILES CC[C@@H](C(=O)N1C[C@H](C[C@H]1CC2=C(NC3=C2C=CC(=C3)F)C4=C(C5=C(N4)C=C(C=C5)F)C[C@@H]6C[C@@H](CN6C(=O)[C@H](CC)NC(=O)[C@H](C)NC)O)O)NC(=O)[C@H](C)NC

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